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rSec6 monoclonal antibody (9H5)
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rSec6 and rSec8 are rat homologs of the yeast Sec6 and Sec8 proteins that are essential for protein transport between the Golgi apparatus and the plasma membrane. In yeast, Sec8 is part of a 19.5S complex that includes Sec6 and Sec15, that also associate with the ras-like GTP binding protein Sec4. An analogous 17S complex in rat brain was found to contain rSec6 and rSec8, along with eight proteins with a combined molecular weight of 743 kDa. The membrane-associated rSec6/8 complex co-immunoprecipitates with syntaxin, providing evidence that this complex is involved in synaptic vesicle docking and fusion at the presynaptic terminal. Immunohistochemistry analysis of human tonsil tissue stained with rSec6, mAb (9H5) at 10µg/ml. Western blot analysis of pig ESK-4 cell lysate, probed with Prod. No. ADI-VAM-SV021. Immunohistochemistry analysis of human tonsil tissue stained with rSec6, mAb (9H5) at 10µg/ml. Western blot analysis of pig ESK-4 cell lysate, probed with Prod. No. ADI-VAM-SV021.
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| Alternative Name Exocyst complex component 3 | Application ICC, IHC (PS), WB | Application Notes Detects a band of ~87kDa by Western blot.2888704-84-3 Biological Activity | Clone 9H5 | Formulation Liquid.2438637-61-5 medchemexpress In PBS, pH 7.PMID:30057217 2, containing 50% glycerol and 0.09% sodium azide. | Host Mouse | Immunogen Recombinant rat Sec6. | Isotype IgG2a | Recommendation Dilutions/Conditions Western Blot (1:250, ECL)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Source Purified from ascites. | Species Reactivity Bovine, Chicken, Dog, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep | Technical Info / Product Notes Recommended by the Human Protein Atlas Organization for IHC (Ensembl No. ENSG00000180104). | UniProt ID Q62825 | Unit of Measure (UM) µg
