Name:
VSIG3/IGSF11 Protein
Synonyms:
VSIG3, IgSF11, CXADRL1, Bt-IgSF, CT119
Species Name:
Human
Label Name:
Human Fc Tag
Marker Name:
Unconjugated
Accession:
Q5DX21-1
Gene Id:
Leu23-Gly241, with C-terminal Human IgG1 FcLEVSESPGSIQVARGQPAVLPCTFTTSAALINLNVIWMVTPLSNANQPEQVILYQGGQMFDGAPRFHGRVGFTGTMPATNVSIFINNTQLSDTGTYQCLVNNLPDIgGRNIGVTGLTVLVPPSAPHCQIQGSQDIGSDVILLCSSEEGIPRPTYLWEKLDNTLKLPPTATQDQVQGTVTIRNISALSSGLYQCVASNAIGTSTCLLDLQVISPQPRNIGIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
Molecular Weight:
55-70kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
VSIG3 (V-set and immunoglobulin domain containing 3) is amember of the immunoglobulin superfamily (IgSF), which is also called theimmunoglobulin superfamily 11 gene (IgSF11), and it is highly expressed in thebrain and testis. Mature human VSIG3 consists of a 219 amino acid (aa)extracellular domain (ECD) that contains two tandem Ig-like domains, a 21 aatransmembrane segment, and a 169 aa cytoplasmic domain. The function of VSIG3is to stimulate cell growth through homophilic interactions. In clinical, theVSIG3 has been reported to as a novel target for cancer immunotherapy ofgastrointestinal and hepatocellular carcinomas. In addition, VSIG-3 is also aligand of B7 family member VISTA/PD-1H and inhibits human T-cell functionsthrough a novel VSIG-3/VISTA pathway.
Reference:
1. Suzu S, Hayashi Y, Harumi T, Nomaguchi K, YamadaM, Hayasawa H, et al. Molecular cloning of a novel immunoglobulin superfamilygene preferentially expressed by brain and testis. Biochem Biophys Res Commun(2002) 296(5):1215–21. doi: 10.1016/s0006-291x(02)02025-9.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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