VHL/Elongin-C/Elongin-B Complex Protein

Name:
VHL/Elongin-C/Elongin-B Complex Protein

Synonyms:
Elongin B & Elongin C & VHL, ELOB & ELOC & VHL Complex, Elongin B & Elongin C & VHL Complex

Species Name:
Human

Label Name:
null

Marker Name:
Unconjugated

Accession:
Q15370、Q15369、P40337

Gene Id:
ELOB flag tag, Human, Asp2-Gln118, N-flagDYKDDDDKDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPDEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALCIEPFSSPPELPDVMKPQDSGSSANEQAVQELOC flag tag, Human, Asp2-Cys112, N-flagDYKDDDDKDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDCVHL His tag, Human, Pro2-Asp213, N-HisHHHHHHHHHHGGGSGGGSPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD

Molecular Weight:
14 kDa (ElOB) and 13.3 kDa (ElOC) and 25.9 kDa (VHL)

Purity:
>95% by SDS-PAGE

Physical Appearance Name:
Liquid

Endotoxin Name:
<0.1EU/μg

Reconstitution:
N.A

Stability Storage:
12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.

Buffer System:
40mM Tris, 200mM NaCl, 2.2mM KCl, 20% glycerol, 3mM DTT, pH8.0

Quality Statement:
ELOB (elongin B) is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units.ELOB and ELOC(elongin C) form a heterodimer that serves as the regulatory subunit for the Elongin complex-a general transcription elongation factor that increases RNA Polymerase II transcription through template-encoded arresting sites. The ELOB/ELOC complex also binds to the \”BC-box motif\” found in many proteins in the VHL-box and SOCS-box protein families. The VHL(von Hippel-Lindau disease tumor suppressor) binds to ELOB and ELOC and thereby inhibits transcription elongation.

Reference:
1.\tCell Chem Biol. 2023 Jul 20;30(7):766-779.e11. doi: 10.1016/j.chembiol.2023.05.012. Epub 2023 Jun 23.2.\tbioRxiv. 2023 May 24;2023.05.22.541439. doi: 10.1101/2023.05.22.541439. PreprintOkumura F., et al. (2012) Front. Oncol. doi: 10.3389/fonc.2012.000103.\tMod Pathol. 2023 Apr 23;36(8):100194. doi: 10.1016/j.modpat.2023.100194. Online ahead of print.

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Author: Adenosylmethionine- apoptosisinducer

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