Name:
IL-31 Protein
Synonyms:
IL-31,IL31,Interleukin-31
Species Name:
Human
Label Name:
No Tag
Marker Name:
Unconjugated
Accession:
Q6EBC2
Gene Id:
Ser24-Thr164MSHTLPVRLLRPSDDVQKIVEELQSLSKMLLKDVEEEKGVLVSQNYTLPCLSPDAQPPNNIHSPAIRAYLKTIRQLDNKSVIDEIIEHLDKLIFQDAPETNISVPTDTHECKRFILTISQQFSECMDLALKSLTSGAQQATT
Molecular Weight:
16kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
20mM PB, 100mM NaCl, pH6.5
Quality Statement:
IL-31 which produced by activated Th2-type T cells. IL-31 signals through a receptor composed of IL-31 receptor A and oncostatin M receptor. IL-31 activates STAT3 and possibly STAT1 and STAT5 through the IL-31 heterodimeric receptor composed of IL31RA and OSMR. IL-31 has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. Patients with atopic dermatitis, chronic spontaneous urticaria, allergic contact dermatitis, prurigo nodularis, primary cutaneous lymphoma and mastocytosis exhibit increased serum levels of IL-31 protein and elevated IL-31 mRNA in the skin.
Reference:
1.J Allergy Clin Immunol. 2023 Jul 13;S0091-6749(23)00888-6. doi: 10.1016/j.jaci.2023.06.023. Online ahead of print.2. Allergy. 2023 Jul 13. doi: 10.1111/all.15816. Online ahead of print.3. Clin Exp Med. 2023 Jul 1. doi: 10.1007/s10238-023-01125-x. Online ahead of print.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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