Name:
Bedinvetmab Protein
Synonyms:
Librela
Species Name:
Canine
Label Name:
null
Marker Name:
Unconjugated
Accession:
Gene Id:
Molecular Weight:
25-30kDa(Light Chain) & 50-55 kDa (Heavy Chain)(Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, PH7.4, 5% trehalose
Quality Statement:
Bedinvetmab is A recombinant canine monoclonal antibody that binds to nerve growth factor (NGF), reduces NGF binding to tropomyosin receptor kinase A (TrkA) and p75 neurotrophin receptor (p75NTR) receptors, and reduces TrkA signaling in pain-related cell types. In vitro binding studies have shown that bedinvetmab binds to NGF with high affinity, but does not bind to other neuronutrients, including human neuronutrient-3 (NT-3), canine and human NT-4, and brain-derived neurotrophic factor (BDNF).
Reference:
1.Corral MJ, Moyaert H, Fernandes T, Escalada M, Kira S Tena J, Walters RR, Stegemann MR. A prospective, randomized, blinded, placebo-controlled multisite clinical study of bedinvetmab, a canine monoclonal antibody targeting nerve growth factor, in dogs with osteoarthritis. Vet Anaesth Analg. 2021 Nov;48(6):943-955. doi: 10.1016/j.vaa.2021.08.001. Epub 2021 Aug 22. PMID: 34565678.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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