Name:
MIG/CXCL9 Protein
Synonyms:
C-X-C motif chemokine 9; MIG; CXCL9; CMK; SCYB9
Species Name:
Human
Label Name:
No Tag
Marker Name:
Unconjugated
Accession:
Q07325
Gene Id:
Thr23-Thr125MTPVVRKGRCSCISTNQGTIHLQSLKDLKQFAPSPSCEKIEIIATLKNGVQTCLNPDSADVKELIKKWEKQVSQKKKQKNGKKHQKKKVLKVRKSQRSRQKKTT
Molecular Weight:
15kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
Monokine induced by IFN-gamma (MIG; CXC chemokine ligand (CXCL)9) is important in T lymphocyte recruitment in organ transplantation. MIG/CXCL9 stimulate CD4 lymphocyte proliferation in a MHC class II-mismatched MLR and also increased the number of IFN-gamma-producing CD4 lymphocytes in ELISPOT. Neutralization of MIG/CXCL9 in MLR reduced T lymphocyte proliferation, IFN-gamma-inducible protein 10/CXCL10 and IFN-inducible T cell alpha chemoattractant/CXCL11 had similar effects on T lymphocyte proliferation. MIG/CXCL9 stimulated T lymphocyte proliferation in MHC class I-and total MHC-mismatched MLRs. Neutralization of CXCR3 reduced MIG/CXCL9-induced T lymphocyte proliferation and the number of IFN-gamma-positive spots on ELISPOT.The proliferative effects of MIG/CXCL9 were mediated via an IL-2-independent pathway and were controlled by IFN-gamma.
Reference:
J Immunol. 2004 Jun 15;172(12):7417-24. doi: 10.4049/jimmunol.172.12.7417. Exp Cell Res. 2021 Oct 15;407(2):112801. doi: 10.1016/j.yexcr.2021.112801. Epub 2021 Aug 27.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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