Name:
IL-2 Protein
Synonyms:
IL-2(Cys145Ser), IL-2 C145S
Species Name:
Human
Label Name:
No Tag
Marker Name:
Unconjugated
Accession:
P60568
Gene Id:
Ala21-Thr153 Cys145SerMAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFSQSIISTLT
Molecular Weight:
15kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
20mM PB, 150mM NaCl, 5% Trehalose, pH 7.4.
Quality Statement:
IL-2(Cys145Ser) is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. It has been engineered to contain the serine for cysteine substitution at amino acid position 145. IL-2(Cys145Ser) has similar characteristics and functions to IL-2, which is a leukocytotrophic hormone that is instrumental in the body natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 is expressed by CD4+ and CD8+ T cells, gamma δ T cells, B cells, dendritic cells, and eosinophils. Mature human IL-2 shares 56% and 66% amino acid (aa) sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit cross-species activity. IL-2 can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells, and plays a vital role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells. Thus, IL-2 may be a key cytokine in the natural suppression of autoimmunity. Recombinant IL-2 is widely used in cell culture for the expansion of T cells.
Reference:
1.Pol, J. G. , Caudana, P. , Paillet, J. , Piaggio, E. , & Kroemer, G. . (2020). Effects of interleukin-2 in immunostimulation and immunosuppression. The Journal of Experimental Medicine(1), 217. 2.Kolios, A. G., Tsokos, G. C., & Klatzmann, D. (2021). Interleukin-2 and regulatory T cells in rheumatic diseases. Nature Reviews Rheumatology, 17(12), 749-766. 3.Zhang, Y., & Su, J. (2023). Interleukin-2 family cytokines: An overview of genes, expression, signaling and functional roles in teleost. Developmental & Comparative Immunology, 104645.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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