Name:
Lecanemab Protein
Synonyms:
Leqembi
Species Name:
null
Label Name:
null
Marker Name:
Unconjugated
Accession:
Gene Id:
Molecular Weight:
25-27 kDa (Light Chain) & 53-55 kDa (Heavy Chain) (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4,5% trehalose
Quality Statement:
Lecanemab is a humanized IgG1 monoclonal antibody that binds to soluble Aβ aggregates (oligomers and protofibrils) with high selectivity over monomer (> 1000-fold) and insoluble fibrils (approximately 10–15 fold). Reduction of Aβ protofibrils and Aβ plaque, as well as prevention of Aβ deposition before plaques develop, has been demonstrated using the murine version of lecanemab in animal models.
Reference:
1. Chad J Swanson, Yong Zhang, Shobha Dhadda, Jinping Wang, June Kaplow, Heather Bradley, Martin Rabe, Akihiko Koyama, Larisa Reyderman, Lynn D Kramer. A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer’s disease with lecanemab, an anti-Aβ protofibril antibody. Alzheimers Res Ther. 2021 Apr 17;13(1):80. doi: 10.1186/s13195-021-00813-8.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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