CD300f/LMIR3/IREM-1 Protein | Adenosylmethionine

Name:
CD300f/LMIR3/IREM-1 Protein

Synonyms:
CD300f, LMIR3, CLM1, IGSF13, IREM-1, NKIR

Species Name:
Human

Label Name:
His Tag

Marker Name:
Unconjugated

Accession:
Q8TDQ1-1

Gene Id:
Thr20-Ser156 TQITGPTTVNGLERGSLTVQCVYRSGWETYLKWWCRGAIWRDCKILVKTSGSEQEVKRDRVSIKDNQKNRTFTVTMEDLMKTDADTYWCGIEKTGNDLGVTVQVTIDPAPVTQEETSSSPTLTGHHLDNRHKLLKLSGGGSHHHHHHHH

Molecular Weight:
20-35kDa (Reducing)

Purity:
＞95% by SDS-PAGE

Physical Appearance Name:
Lyophilized Powder

Endotoxin Name:
<0.1EU/μg

Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.

Buffer System:
1*PBS, PH7.4, 5% trehalose

Quality Statement:
LMIR3, also known as CD300f, CD300LF, IREM-1, CLM-1, IgSF13, DIgR1, and MAIR-V, is a 50-60 kDa glycoprotein member of the immunoglobulin superfamily. Human LMIR3 consists of a 137 amino acid (aa) extracellular domain (ECD) with one Ig-like V-type domain, a 21 aa transmembrane segment, and a 113 aa cytoplasmic domain that contains multiple immunoreceptor tyrosine-based inhibitory motifs (ITIMs) or ITIM-like sequences. Within the ECD, human LMIR3 shares 43% aa sequence identity with mouse and rat LMIR3. LMIR3 is expressed on the surface of dendritic cells, monocytes, granulocytes, and mast cells as well as on acute myeloid leukemia (AML) blasts. LMIR3 is up-regulated on monocytes surrounding experimentally-induced spinal cord demyelination and functions as a negative regulator of inflammation in the CNS.

Reference:
Clark, G.J. et al. (2009) Trends Immunol. 30:209.Sui, L. et al. (2004) Biochem. Biophys. Res. Commun. 319:920.Alvarez-Errico, D. et al. (2004) Eur. J. Immunol. 34:3690.Korver, W. et al. (2009) Leukemia 23:1587.

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Author: Adenosylmethionine- apoptosisinducer

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