Name:
VEGF-121 Protein
Synonyms:
Vascular Endothelial Growth Factor A, VEGFA
Species Name:
Human
Label Name:
No Tag
Marker Name:
Unconjugated
Accession:
P15692-9
Gene Id:
Ala27-Arg147 MAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVDIFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEMSFLQHNKCECRPKKDRARQEKCDKPRR.
Molecular Weight:
14kDa
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.
Buffer System:
20mM PB, 150mM NaCl, pH 7.4
Quality Statement:
VEGF-121, an abundant splicing isoform of vascular endothelial growth factor (VEGF), exists as a disulfide-linked homodimer. It induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Contrast to other isoforms, VEGF-121 has very little affinity for heparin-sulfate proteoglycans, without recruiting Neuropilin1-expressing monocytes (NEMs), conferring to VEGF-121 the ability to diffuse freely, and increase tumor growth rate in vivo.
Reference:
1.\tFASEB J. 2001 Jul;15(9):1667-9.doi: 10.1096/fj.00-0757fje.2.\tCancer Gene Ther. 2016 May;23(5):125-32. doi: 10.1038/cgt.2016.12. Epub 2016 Apr 1.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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