Name:
TGFBR3 Protein
Synonyms:
TBRIII, TGF-beta receptor type 3
Species Name:
Human
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
Q03167-1
Gene Id:
Gly21-Val787GPEPGALCELSPVSASHPVQALMESFTVLSGCASRGTTGLPQEVHVLNLRTAGQGPGQLQREVTLHLNPISSVHIHHKSVVFLLNSPHPLVWHLKTERLATGVSRLFLVSEGSVVQFSSANFSLTAETEERNFPHGNEHLLNWARKEYGAVTSFTELKIARNIYIKVGEDQVFPPKCNIGKNFLSLNYLAEYLQPKAAEGCVMSSQPQNEEVHIIELITPNSNPYSAFQVDITIDIRPSQEDLEVVKNLILILKCKKSVNWVIKSFDVKGSLKIIAPNSIGFGKESERSMTMTKSIRDDIPSTQGNLVKWALDNGYSPITSYTMAPVANRFHLRLENNAEEMGDEEVHTIPPELRILLDPGALPALQNPPIRGGEGQNGGLPFPFPDISRRVWNEEGEDGLPRPKDPVIPSIQLFPGLREPEEVQGSVDIALSVKCDNEKMIVAVEKDSFQASGYSGMDVTLLDPTCKAKMNGTHFVLESPLNGCGTRPRWSALDGVVYYNSIVIQVPALGDSSGWPDGYEDLESGDNGFPGDMDEGDASLFTRPEIVVFNCSLQQVRNPSSFQEQPHGNITFNMELYNTDLFLVPSQGVFSVPENGHVYVEVSVTKAEQELGFAIQTCFISPYSNPDRMSHYTIIENICPKDESVKFYSPKRVHFPIPQADMDKKRFSFVFKPVFNTSLLFLQCELTLCTKMEKHPQKLPKCVPPDEACTSLDASIIWAMMQNKKTFTKPLAVIHHEAESKEKGPSMKEPNPISPPIFHGLDTLTVGGGSGGGSHHHHHHHHHH
Molecular Weight:
97-180kDa (Reducing)
Purity:
>95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4.
Quality Statement:
Type III receptor (TGFBR3), also known as beta-glycan, is essential and the most abundant receptor that mediates TGF-β signaling. As a high-affinity co-receptor for TGF-β, upon ligand binding, TGFBR3 facilitates ligand binding of TGFBR2, which phosphorylates and activates TGFBR1 kinase activity. Transforming growth factor beta receptor III (TGFBR3) functions as a binding co‐receptor for various cytokines of the TGF‐β superfamily and is thought to play a role in the pathogenesis of some human cancers. Some reports have suggested that TGFBR3 promotes the growth, migration, invasion and metastasis of colon cancer. In contrast, some evidences indicate that TGFBR3 contributes to reduced angiogenesis, tumour invasion and metastasis, and its expression is decreased or absent in most human cancers including breast, liver, lung, kidney, pancreas and prostate cancers.
Reference:
Gatza CE, Holtzhausen A, Kirkbride KC, et al. Type III TGF‐β receptor enhances colon cancer cell migration and anchorage‐independent growth. Neoplasia. 2011; 13:758‐770. Vander Ark A., Cao J., Li X. TGF-beta receptors: In and beyond TGF-beta signaling. Cell Signal. 2018; 52:112–120. doi: 10.1016/j.cellsig.2018.09.002.Wang X.F., Lin H.Y., Ng-Eaton E., Downward J., Lodish H.F., Weinberg R.A. Expression cloning and characterization of the TGF-beta type III receptor. Cell. 1991; 67:797–805. doi: 10.1016/0092-8674(91)90074-9.
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