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Name:
USP14 Protein

Synonyms:
Ubiquitin carboxyl-terminal hydrolase 14, Deubiquitinating enzyme 14, Ubiquitin thioesterase 14, Ubiquitin-specific-processing protease 14

Species Name:
Human

Label Name:
His Tag

Marker Name:
Unconjugated

Accession:
P54578

Gene Id:
Pro2-Gln494MHHHHHHHHPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKIKNGMTLLMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATVQCIRSVPELKDALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQYLQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSSASAATPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLEDKKVNQQPNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVEIMEEESEQ

Molecular Weight:
57 kDa (Reducing)

Purity:
>95% by SDS-PAGE&SEC-HPLC

Physical Appearance Name:
Lyophilized Powder

Endotoxin Name:
<0.1EU/μg

Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.

Buffer System:
PBS, pH7.4

Quality Statement:
Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme (DUB), is associated withproteasomes and exerts a dual function in regulating protein degradation. USP14 protectsprotein substrates from degradation by removing ubiquitin chains from proteasome-boundsubstrates, whereas promotes protein degradation by activating the proteasome. Increasingevidence have shown that USP14 is involved in several canonical signaling pathways, correlating with cancer, neurodegenerative diseases, autophagy, immune responses, andviral infections. The activity of USP14 is tightly regulated to ensure its function in various cellular processes. Due to its intriguing roles in the stabilization of disease-causing proteins and oncology targets, USP14 has garnered widespread interest as a therapeutic target.

Reference:
Front Pharmacol. 2022 Jan 5:12:801328. doi: 10.3389/fphar.2021.801328​J Cell Physiol. 2021 May;236(5):3396-3405. doi: 10.1002/jcp.30124​. Epub 2020 Nov 1

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Author: Adenosylmethionine- apoptosisinducer