Name:
CD45 Protein
Synonyms:
PTPRC, L-CA, T200
Species Name:
Human
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
P08575
Gene Id:
Gln26-Lys577,with C-terminal 10*His QSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKGGGSGGGSHHHHHHHHHH
Molecular Weight:
95-150kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
CD45 is anevolutionary highly conserved receptor protein tyrosine phosphatase exclusivelyexpressed on all nucleated cells of the hematopoietic system. It is characterizedby the expression of several isoforms, specific to a certain cell type and thedevelopmental or activation status of the cell. CD45 is one of the key playersin the initiation of T cell receptor signaling by controlling the activation ofthe Src family protein-tyrosine kinases Lck and Fyn. CD45 deficiency results inT- and B-lymphocyte dysfunction in the form of severe combined immunedeficiency. It also plays a significant role in autoimmune diseases and canceras well as in infectious diseases including fungal infections. The knowledgecollected on CD45 biology is rather vast, but it remains unclear whether allfindings in rodent immune cells also apply to human CD45.
Reference:
1. Andreas Rheinländer. CD45 in human physiology and clinical medicine. Immunol Lett. 2018 Apr;196:22-32. doi: 10.1016/j.imlet.2018.01.009. Epub 2018 Jan 31.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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