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Name:
Biotinylated CD4/LEU3 Protein

Synonyms:
T4, IMD79, Leu-3, OKT4D, CD4mut

Species Name:
Cynomolgus

Label Name:
Avi Tag, His Tag

Marker Name:
Biotin

Accession:
P79185

Gene Id:
Lys26-Pro396KKVVLGKKGDTVELTCNASQKKNTQFHWKNSNQIKILGIQGSFLTKGPSKLSDRADSRKSLWDQGCFSMIIKNLKIEDSDTYICEVENKKEEVELLVFGLTANSDTHLLEGQSLTLTLESPPGSSPSVKCRSPGGKNIQGGRTLSVPQLERQDSGTWTCTVSQDQKTVEFKIDIVVLAFQKASSTVYKKEGEQVEFSFPPAFTLEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQFQENLTCEVWGPTSPKLTLSLKLENKGTTVSKQAKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVVPTWPTPVQPGGGSGGGSHHHHHHHHHHGLNDIFEAQKIEWHE

Molecular Weight:
50-55kDa (Reducing)

Purity:
>95% by SDS-PAGE

Physical Appearance Name:
Lyophilized Powder

Endotoxin Name:
<1EU/μg

Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.

Buffer System:
PBS, pH7.4.

Quality Statement:
The cluster of differentiation 4 receptor (CD4) is a 55kDa type I integral membrane glycoprotein which plays a substantial role during adaptive immune responses. In T-cells, CD4 mediates maturation, stabilizes T-cell receptor interactions with peptide-major histocompatibility complex class II (MHCII) complexes on antigen presenting cells, and mediates intracellular T-cell signalling.2 In addition to T-cells, CD4 has also been shown to be expressed on monocytes, monocyte-derived macrophages, Langerhans cells, B lymphocytes, dendritic cells, eosinophils, megakaryocytes and mast cells. The role of CD4 during immune function can also be diverted by the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein gp120 as the viral receptor utilizes CD4 as the primary receptor as well as the co-receptor CCR5/CXCR4 during the entry process.

Reference:
1. Gavin R Owen, (2016) Human CD4 Metastability Is a Function of the Allosteric Disulfide Bond in Domain 2. Biochemistry. 55(15):2227-37.

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Author: Adenosylmethionine- apoptosisinducer