Name:
Endo S Protein
Synonyms:
Endo-beta-N-acetylglucosaminidase EndoS, Endoglycosidase S, EndoS
Species Name:
Streptococcus pyogenes
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
Q99Y92
Gene Id:
Molecular Weight:
109 Da (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Liquid
Endotoxin Name:
null
Reconstitution:
Stability Storage:
Store at -25 ~ -15℃for 2 years
Buffer System:
20 mM Tris-HCl、50 mM NaCl、5 mM EDTA（pH 7.5 @ 25°C）
Quality Statement:
Anenzyme expressed by Streptococcus pyogenes capable of releasing theterminal sialic acid residues from glycoproteins such as immunoglobulins.Specifically catalyzes the hydrolysis of the beta-1,4 linkage betweenthe first two N-acetylglucosamine residues of the complex-type N-linked glycanlocated on ‘Asn-297’ of the Fc region of IgG antibodies (IGHG1, IGHG2, IGHG3 orIGHG4), thereby preventing interaction between IgGs and Fc receptors andability to activate the complement pathway. Endo S is an endoglycosidasespecific for cleaving the N-linked glycans from the chitobiose core of theheavy chain of native IgG.
Reference:
[1]Collin,M.EndoS, a novel secreted protein from Streptococcus pyogenes withendoglycosidase activity on human IgG[J].Embo Journal, 2014,20(12):3046-3055.DOI:10.1093/emboj/20.12.3046. [2] Beatriz,Trastoy,Joseph,et al.Liquid–liquiddiffusion crystallization improves the X-ray diffraction of EndoS, anendo-β-N-acetylglucosaminidase from Streptococcus pyogenes with activity onhuman IgG[J].Acta Crystallographica, 2013.DOI:10.1107/S1744309113030650.
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