Name:
4-1BB/TNFRSF9 Protein
Synonyms:
TNFRSF9; 4-1BB; CD137; CDw137; ILA
Species Name:
Rabbit
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
G1SHD7
Gene Id:
Val29 -Ile191VQGPCANCPAGTFCGKSRNPIFVPCPPNSLSCGSGQRTCVLCRRCEGVFRTKKPCSPTSDTECECIAGFHCLGPGCSMCEQDCEQGQEFTKEGCKDCPFGSFNNQKGGICQPWTNCSGGRPVLVNGTKDSDVVCGPTAPGFSPGASSTTSPPPPPAGHSPQVIGGGSHHHHHHHH
Molecular Weight:
27-33kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4.
Quality Statement:
CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses.
Reference:
Melero I, et al. (2008) Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies. Trends Pharmacol Sci. 29(8): 383-90.Thum E, et al. (2009) CD137, implications in immunity and potential for therapy. Front Biosci. 14: 4173-88.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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