Name:
TRAIL R1/TNFRSF10A Protein
Synonyms:
Death receptor 4TRAIL receptor 1; TRAIL-R1; TNFRSF10A
Species Name:
Human
Label Name:
Human Fc Tag
Marker Name:
Unconjugated
Accession:
O00220
Gene Id:
Ala109-Asn239ATIKLHDQSIGTQQWEHSPLGELCPPGSHRSEHPGACNRCTEGVGYTNASNNLFACLPCTACKSDEEERSPCTTTRNTACQCKPGTFRNDNSAEMCRKCSRGCPRGMVKVKDCTPWSDIECVHKESGNGHNIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
Molecular Weight:
44-49kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4.
Quality Statement:
TNFSFR10A, also known as death receptor 4, DR4, and TNF-related apoptosis-inducing ligand receptor 1, TRAIL-R1, is a member of the TNF receptor superfamily. TNFSFR10A can be expressed by spleen, peripheral blood leukocytes, small intestine and thymus,but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. TNFSFR10A encodes a cell surface receptor involved in apoptotic, necroptotic, and inflammatory cell-signaling pathways. TNFRSF10A serves as a receptor for the cytokine TNF-related apoptosis-inducing ligand (TRAIL) in death receptor signaling pathways and has also been shown to be involved in the activation of NFκβ inflammatory signaling pathways.
Reference:
Feoktistova M, Geserick P, Panayotova-Dimitrova D, Leverkus M. Pick your poison: the Ripoptosome, a cell death platform regulating apoptosis and necroptosis. Cell Cycle. 2012; 11:460–7. doi: 10.4161/cc.11.3.19060.Hughes MA, Langlais C, Cain K, MacFarlane M. Isolation, characterisation and reconstitution of cell death signalling complexes. Methods. 2013; 61:98–104. doi: 10.1016/j.ymeth.2013.02.006. Wajant H. TRAIL and NFkappaB signaling-a complex relationship. Vitam Horm. 2004; 67:101–32. doi: 10.1016/S0083-6729(04)67007-5.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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