Name:
Saposin-A Protein
Synonyms:
Proactivator polypeptide; Saposin-A; PSAP; GLBA; SAP1
Species Name:
Human
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
P07602
Gene Id:
Ser60-Ser140MHHHHHHSSGVDLGTENLYFQSMGSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCES
Molecular Weight:
10kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Liquid
Endotoxin Name:
<1EU/μg
Reconstitution:
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
20 mM HEPES, 150 mM NaCl, pH 7.5 \n
Quality Statement:
Saposin-A is a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D, which are similar to each other and are sphingolipid hydrolase activator proteins. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities.
Reference:
1. 2020 Feb;129(2):161-164. doi: 10.1016/j.ymgme.2019.08.001. Epub 2019 Aug 5.2. 2013 Jun 15;22(12):2435-50. doi: 10.1093/hmg/ddt096. Epub 2013 Feb 27
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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