MIP-1α/CCL3 Protein

Quality Statement:
Chemokines are a class of cytokines that can cause cells to undergochemotactic movement, and their main role in the body is in chemotactic cellmigration. They are widely expressed in various tissues and cells of the body,and their receptors are mainly expressed in white blood cells, mediating thedirectional migration of white blood cells to play a biological role. CCL3, oneof the components of the chemokinep CC ligand family was also termed as MIP(macrophage inflammatory protein). It can be expressed on the surface ofmacrophages, lymphocytes, epithelial cells, and other cells. It mediates thesecretion of cytokines by immune cells and promotes the aggregation andmigration of a variety of cells. C-C motif chemokine receptor 1 (CCR1) and CCR5are the receptors of CCL3.C-C motif chemokine ligand 3 (CCL3) belongs toinflammatory cell chemokine. CCL3 or macrophageinflammatory protein-1α (MIP-1α), an important chemokine implicated in bothimmune surveillance and tolerance, has emerged as a prognostic biomarker inboth solid and hematological malignancies.

Reference:
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