Name:
NRG1/Heregulin-β1 Protein
Synonyms:
Pro-neuregulin-1;Neuregulin-1 beta 1;NRG1-beta 1;HRG1-beta 1; EGF;NRG1; GGF; HGL; HRGA; NDF; SMDF
Species Name:
Human
Label Name:
No Tag
Marker Name:
Unconjugated
Accession:
Q02297-6
Gene Id:
Ser177-Glu241SHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAE
Molecular Weight:
7-8kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS,pH7.4.
Quality Statement:
Heregulin-β also known as neuregulin-1 (NRG-1) is a member of the epidermal growth factor (EGF) family of growth factors and acts as a ligand for ErbB family receptor tyrosine kinases. And NRG1 isoforms can signal in a paracrine, autocrine, or juxtacrine manner, playing a fundamental role during the development of the peripheral nervous system and during the process of nerve repair, suggesting that the treatment with NRG1 could improve functional outcome following injury. The NRG1 receptors are membrane-spanning receptor tyrosin kinases of the ErbB family (ErbB1–4), of which the EGF receptor (ErbB1) is the most prominent representative.
Reference:
Cell Rep. 2021 Sep 7;36(10):109656. doi: 10.1016/j.celrep.2021.109656. Cell Rep. 2021 Aug 17;36(7):109538. doi: 10.1016/j.celrep.2021.109538.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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