Name:
Nectin-4 Protein
Synonyms:
PRR4，LNIR，Nectin cell adhesion molecule 4，PVRL4，Ig superfamily receptor LNIR，Poliovirus receptor-related protein 4，NECTIN4，Poliovirus Receptor-Related 4，Nectin-4，Nectin 4，EDSS1
Species Name:
Rat
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
D3ZET1
Gene Id:
Tyr28-Val348 YSAGELETSDLVTVVLGQDAKLPCFYRGDPDEQVGQVAWARVDPNEGTRELALLHSKYGLHVSPAYEDRVEQPPPPRDPLDGSILLRNAVQADEGEYECRVSTFPAGSFQARMRLRVLVPPLPSLNPGPPLEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTQSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHTLQVAFLAEASVRGLEDQNLWHVGREGATLKCLSEGQPPPKYNWTRLDGPLPSGVRVKGDTLGFPPLTTEHSGVYVCHVSNELSSRASQVTVEVLADPEDPGKQVDLVSASGGGSHHHHHHHH
Molecular Weight:
40-42kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4.
Quality Statement:
Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins. Nectin extracellular domains (ECDs) contain three Ig-like domains: an N-terminal V-type that mediates ligand binding, and two C2-type .Human Nectin-4 is normally expressed in the placenta, especially in endothelial cells, while in the mouse it is found in the embryo, lung, testis and brain. In humans, mutation of Nectin-4 has been correlated with ectodermal dysplasia-syndactyly syndrome,High Nectin-4/PVRL4 expression was associated with poor-prognosis in some invasive breast cancers and may be a new promising prognostic biomarker and specific therapeutic target.
Reference:
1. Reymond, N. et al. (2001) J. Biol. Chem. 276:43205.2.Takai, Y. et al. (2008) Nat. Rev. Mol. Cell Biol. 9:603.3.Fabre, S. et al. (2002) J. Biol. Chem. 277:27006.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
KIRREL2/NEPH3 Protein
C-Reactive Protein
Popular categories:
IL-1 Receptor Accessory Proteins
B Cell Maturation Antigen (BCMA)
