FCER1a Protein

Quality Statement:
Fc epsilon RI α, also known as FCER1A, is the αsubunit of immunoglobulin receptor (IgE receptor). IgE receptor consists of oneα subunit, one β subunit and two γ subunits. The α subunit includesextracellular domain and transmembrane domain, and the extracellular regioncontains two immunoglobulin-like domains, in which the proximal membrane end isthe binding region to IgE Fc, and the other end is related to high affinity.The α subunit contains seven N-chain glycosylation sites, which can guide thecorrect folding of the α-chain. β subunit is divided into transmembrane regionand intracellular region, which is a four-time transmembrane molecule withimmune receptor tyrosine activation motif (ITAM). The γ subunits are connectedby disulfide bonds and each has a transmembrane region. Fc epsilon RI α firstinitiates anaphylaxis. Allergens act on mast cells through IgE and Fc epsilonRI α, activate chemical mast cells through signal transduction, releasevasoactive mediators such as histamine and bradykinin to causehypersensitivity, or pre-release Leucotrienes, leukotrienes and plateletactivating factors to cause inflammation.

Reference:
1. Shimizu, A. et al. (1988) Proc. Natl. Acad. Sci. USA 85:1907.