Name:
FCER1a Protein
Synonyms:
FCE1A, FcERI, Fc epsilon RI α
Species Name:
Mouse
Label Name:
Human Fc Tag
Marker Name:
Unconjugated
Accession:
P20489-1
Gene Id:
Ala24-Gln204ATEKSVLTLDPPWIRIFTGEKVTLSCYGNNHLQMNSTTKWIHNGTVSEVNSSHLVIVSATVQDSGKYICQKQGLFKSKPVYLNVTQDWLLLQTSADMVLVHGSFDIRCHGWKNWNVRKVIYYRNDHAFNYSYESPVSIREATLNDSGTYHCKGYLRQVKYESDKFRIAVVKAYKCKYYWLQIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
Molecular Weight:
60-80kDa (Reducing)
Purity:
＞95% by SDS-PAGE & SEC-HPLC
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to-70 °C as supplied. ·1 month, 2 to 8 °C under sterileconditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4.
Quality Statement:
Fc epsilon RI α, also known as FCER1A, is the αsubunit of immunoglobulin receptor (IgE receptor). IgE receptor consists of oneα subunit, one β subunit and two γ subunits. The α subunit includesextracellular domain and transmembrane domain, and the extracellular regioncontains two immunoglobulin-like domains, in which the proximal membrane end isthe binding region to IgE Fc, and the other end is related to high affinity.The α subunit contains seven N-chain glycosylation sites, which can guide thecorrect folding of the α-chain. β subunit is divided into transmembrane regionand intracellular region, which is a four-time transmembrane molecule withimmune receptor tyrosine activation motif (ITAM). The γ subunits are connectedby disulfide bonds and each has a transmembrane region. Fc epsilon RI α firstinitiates anaphylaxis. Allergens act on mast cells through IgE and Fc epsilonRI α, activate chemical mast cells through signal transduction, releasevasoactive mediators such as histamine and bradykinin to causehypersensitivity, or pre-release Leucotrienes, leukotrienes and plateletactivating factors to cause inflammation.
Reference:
1. Shimizu, A. et al. (1988) Proc. Natl. Acad. Sci. USA 85:1907.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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