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Name:
PDGF R alpha/PDGFRA Protein

Synonyms:
CD140A, PDGFR2, RHEPDGFRA, MGC74795

Species Name:
Human

Label Name:
His Tag

Marker Name:
Unconjugated

Accession:
P16234-1

Gene Id:
Gln24-Glu524QLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYPMSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIYVPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNGTFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSEGGGSGGGSHHHHHHHHHH

Molecular Weight:
72-90kDa (Reducing)

Purity:
>95% by SDS-PAGE

Physical Appearance Name:
Lyophilized Powder

Endotoxin Name:
<0.1EU/μg

Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.

Buffer System:
PBS, pH7.4.

Quality Statement:
PDGFR-α has been shown to regulate angiogenesis both in normal and pathological conditions, mainly stimulating the production of vascular endothelial growth factor (VEGF).PDGFR-α is expressed and active in several human malignancies. The most common alterations that lead to active PDGFR-α signaling in solid tumors are gene amplification in subsets of aggressive gliomas and non-small cell lung cancers,and activating mutations in c-KIT-negative GISTs. Among other cancers, PDGFR-α is also overexpressed in ~40% of hepatocellular carcinomas,~20% of non-GIST sarcomas,and ~15% of serous ovarian carcinoma.Finally, PDGFR-α translocations have been found in hematologic malignancies of the eosinophil lineage. Notably, in malignant conditions PDGFR-α expression is usually not confined to cancer cells, but is also present in tumor-associated stromal cells, which provide paracrine factors that stimulate angiogenesis and extracellular matrix remodeling.Finally, PDGFR-α expression has been shown to be correlated to aggressive disease and significantly worse patient survival in pediatric high-grade gliomas and hepatocellular carcinoma.

Reference:
Bruno Vincenzi. Andrea Napolitano.Mariella Spalato Ceruso. Francesco Pantano . Daniele Santini. Giuseppe Tonini. Olaratumab: PDGFR-α inhibition as a novel tool in the treatment of advanced soft tissue sarcomas. Crit Rev Oncol Hematol. 2017 Oct:118:1-6. doi: 10.1016/j.critrevonc.2017.06.006. Epub 2017 Jul 15.

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Author: Adenosylmethionine- apoptosisinducer