Name:
Leptin Protein
Synonyms:
LEPD, Obesity protein (OB), LEP
Species Name:
Human
Label Name:
No Tag
Marker Name:
Unconjugated
Accession:
P50596
Gene Id:
Val22-Cys167MVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGLDFIPGLHPILTLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLPWASGLETLDSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC
Molecular Weight:
16kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
20mM Tris, 80mM NaCl, 5%trehalose, pH8.0
Quality Statement:
Leptin (LEP) is a 16kDa peptide hormone produced mainly by white adipocyte tissue. Leptin is involved in maintaining gastric epithelial cell integrity and gastroprotection. In rats, systemic Leptin is effective in attenuating both ethanol- and aspirin-induced damage to the gastric mucosa. This is correlated with an increase of Leptin production by the stomach during experimentally-induced gastric damage in rats and during H pylori infection in humans. This gastric cytoprotective effect of Leptin involves an increase in blood flow, local production of nitric oxide and prostaglandin E2, and vagus nerve-dependent mechanisms. One of the important functions of Leptin is its role in the regulation of inflammatory processes. There is indeed a large body of evidence that Leptin-mediated signal pathways play an active role in innate and adaptive immunity through alteration of various target genes transcription.
Reference:
1.Handbook of Biologically Active Peptides (Second Edition), 2013, Pages 1251-1256 2.Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy, 2011, Pages 87-104
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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