IdeS Protease Protein | Adenosylmethionine

Name:
IdeS Protease Protein

Synonyms:
IdeS

Species Name:
Streptococcus pyogenes

Label Name:
No Tag

Marker Name:
Unconjugated

Accession:
F8V4V0

Gene Id:

Molecular Weight:
37.7 kDa (Reducing)

Purity:
＞95% by SDS-PAGE

Physical Appearance Name:
Liquid

Endotoxin Name:
null

Reconstitution:

Stability Storage:
·12 months from date of receipt, -20 to-70 °C as supplied. ·1 month, 2 to 8 °C under sterileconditions ·Please avoid repeated freeze-thaw cycles.

Buffer System:
PBS pH 6.6

Quality Statement:
IdeS Protease is a cysteine hydrolase secretedby the human pathogen Streptococcus pyogenes. This product use E. colirecombinant expression, high purity, has good enzyme digestion activity, canspecifically identify IgG, and perform enzyme digestion at specific sites inthe hinge region of the antibody, and IgG can be hydrolyzed into F(ab’)2fragments and Fc fragments, which can identify human and other animal IgG, suchas mouse, rabbit, monkey, sheep and human animal chimeric IgG, etc, It can beused for structural characterization analysis of antibodies and fusion proteindrugs

Reference:
[1]Vincents B, Von Pawel-Rammingen U, Bj?Rck L ,et al.Enzymatic characterizationof the streptococcal endopeptidase, IdeS, reveals that it is a cysteineprotease with strict specificity for IgG cleavage due to exositebinding.[J].Biochemistry, 2004, 43(49):15540-15549.DOI:10.1021/bi048284d.[2] Pawel-Rammingen V, U. IdeS, a novelstreptococcal cysteine proteinase with unique specificity for immunoglobulinG[J]. Embo Journal, 2014, 21(7):1607-1615. DOI:10.1093/emboj/21.7.1607.

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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Author: Adenosylmethionine- apoptosisinducer

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