Name:
IdeS Protease Protein
Synonyms:
IdeS
Species Name:
Streptococcus pyogenes
Label Name:
No Tag
Marker Name:
Unconjugated
Accession:
F8V4V0
Gene Id:
Molecular Weight:
37.7 kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Liquid
Endotoxin Name:
null
Reconstitution:
Stability Storage:
·12 months from date of receipt, -20 to-70 °C as supplied. ·1 month, 2 to 8 °C under sterileconditions ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS pH 6.6
Quality Statement:
IdeS Protease is a cysteine hydrolase secretedby the human pathogen Streptococcus pyogenes. This product use E. colirecombinant expression, high purity, has good enzyme digestion activity, canspecifically identify IgG, and perform enzyme digestion at specific sites inthe hinge region of the antibody, and IgG can be hydrolyzed into F(ab’)2fragments and Fc fragments, which can identify human and other animal IgG, suchas mouse, rabbit, monkey, sheep and human animal chimeric IgG, etc, It can beused for structural characterization analysis of antibodies and fusion proteindrugs
Reference:
[1]Vincents B, Von Pawel-Rammingen U, Bj?Rck L ,et al.Enzymatic characterizationof the streptococcal endopeptidase, IdeS, reveals that it is a cysteineprotease with strict specificity for IgG cleavage due to exositebinding.[J].Biochemistry, 2004, 43(49):15540-15549.DOI:10.1021/bi048284d.[2] Pawel-Rammingen V, U. IdeS, a novelstreptococcal cysteine proteinase with unique specificity for immunoglobulinG[J]. Embo Journal, 2014, 21(7):1607-1615. DOI:10.1093/emboj/21.7.1607.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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