Name:
Leptin R/CD295 Protein
Synonyms:
LEP-R, HuB219, OB receptor (OB-R), CD295
Species Name:
Human
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
P48357
Gene Id:
Phe22-Asp839, with C-terminal 10*HisFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDGGGSGGGSHHHHHHHHHH
Molecular Weight:
100-120kDa
Purity:
>95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
Leptin cellular actions are mediated by leptin receptors (OB-Rs, Leptin R), which are membrane-anchored molecules binding to leptin and transducing its intracellular signal. Leptin R is encoded by the db gene. Leptin R is a member of cytokine receptor family that including various interleukins, interferon-γ, erythropoietin, growth hormone and prolactin. Proteolytic cleavage of transmembrane Leptin R produces a soluble leptin binding protein called soluble leptin receptor (sOB-R), which constitutes the major binding protein of circulating leptin in human plasma. The sOB-R exerts high affinity in binding leptin, antagonizing the membrane leptin receptors and, functionally, inactivating leptin. By binding circulating leptin, sOB-R modulates the bioavailability and efficacy of leptin, exerting a predominantly inhibitory effect on leptin signal transduction; thus, altering the sensitivity of target tissues to leptin actions and producing a state called leptin resistance in analogy to in sulin resistance. Genetic deficiency of either leptin or Leptin R causes severe obesity and obesity-associated diabetes.
Reference:
1.\tBj?rbaek C, Uotani S, da Silva B, Flier JS. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem. 1997;272:32686-32695. doi: 10.1074/jbc.272.51.32686.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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