Name:
IL-31RA Protein
Synonyms:
IL-31 receptor subunit alpha, IL-31R subunit alpha, IL-31R-alpha, IL-31RA
Species Name:
Mouse
Label Name:
Human Fc
Marker Name:
Unconjugated
Accession:
Q8K5B1-1
Gene Id:
Val19-Thr499, with C-terminal Human IgG1 FcVLPTKPENISCVFYFDRNLTCTWRPEKETNDTSYIVTLTYSYGKSNYSDNATEASYSFPRSCAMPPDICSVEVQAQNGDGKVKSDITYWHLISIAKTEPPIILSVNPICNRMFQIQWKPREKTRGFPLVCMLRFRTVNSSHWTEVNFENCKQVCNLTGLQAFTEYVLALRFRFNDSRYWSKWSKEETRVTMEEVPHVLDLWRILEPADMNGDRKVRLLWKKARGAPVLEKTFGYHIQYFAENSTNLTEINNITTQQYELLLMSQAHSVSVTSFNSLGKSQEAILRIPDVHEKTFQYIKSMKAYIAEPLLVVNWQSSIPAVDTWIVEWLPEAAMSKFPALSWESVSQVTNWTIEQDKLKPFTCYNISVYPVLGHRVGEPYSIQAYAKEGTPLKGPETRVENIGLRTATITWKEIPKSARNGFINNYTVFYQAEGGKELSKTVNSHALQCDLESLTRRTSYTVWVMASTRAGGTNGVRINFKTIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
Molecular Weight:
97-120kDa
Purity:
>95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
Interleukin-31 receptor subunit alpha (IL-31RA) is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha. The IL-31RA belongs to the type I cytokine receptor family. The 732 amino acid (aa) IL-31 RA contains signal sequence, extracellular domain (ECD), transmembrane domain and cytoplasmic domain. IL-31RA with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. IL-31 RA is also expressed on keratinocytes, dorsal root ganglia neurons, and variably on lung epithelial cells. IL-31RA functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR).
Reference:
1.\tDillon, S. R. et al. (2004) Nat. Immunol. 5:752.2.\tChattopadhyay, S. et al. (2007) J. Biol. Chem. 282:3014.3.\tPerrigoue, J. G. et al. (2007) J. Exp. Med. 204:481.4.\tBando, T. et al. (2006) Neuroscience 142:1263.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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