Name:
CD221/IGF1R Protein
Synonyms:
Insulin-like growth factor I receptor (IGF-I receptor)
Species Name:
Human
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
P08069
Gene Id:
Glu31-Asn932, with C-terminal 10*HisEICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTAADTYNITDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGYENGGGSGGGSHHHHHHHHHH
Molecular Weight:
45-52kDa
Purity:
>95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
The insulin-like growth factor 1 receptor (IGF1R) is a ubiquitously expressed membrane -bound tyrosine kinase receptor that recognizes its two major ligands IGF1 and IGF2, and controls multiple essential cellular functions. IGF1R is highly overexpressed in tumors, including melanomas, cancers of the colon, pancreas prostate and kidney. IGF1R precursor Cleavage generates alpha and beta subunits. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. IGF1R promotes metastatic tumor initiation and progression in lung TME. IGF1R signaling has been profusely implicated as a critical contributor to cancer cell proliferation, survival, migration, and resistance to anticancer therapies, thus targeting IGF signaling is an attractive therapeutic strategy.
Reference:
1.\tGirnita L, Worrall C, Takahashi SI, Seregard S, Girnita A. Something old, something new and something borrowed: Emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation. Cell Mol Life Sci. 2014;71:2403-27. doi: 10.1007/s00018-013-1514.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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