Name:
IL-31 Protein
Synonyms:
IL-31,IL31,Interleukin-31
Species Name:
Canine
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
C7G0W1
Gene Id:
Ser24-Gln159 with C terminal 8*HisMSHMAPTHQLPPSDVRKIILELQPLSRGLLEDYQKKETGVPESNRTLLLCLTSDSQPPRLNSSAILPYFRAIRPLSDKNIIDKIIEQLDKLKFQHEPETEISVPADTFECKSFILTILQQFSACLESVFKSLNSGPQHHHHHHHH
Molecular Weight:
17kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
econstitute at 0.1-0.5mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4, 5% Trehalose.
Quality Statement:
IL-31which produced by activated Th2-type T cells. IL-31 signals through a receptorcomposed of IL-31 receptor A and oncostatin M receptor. IL-31 activates STAT3and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composedof IL31RA and OSMR. IL-31 has also been identified as a major player in anumber of chronic inflammatory diseases, including atopic dermatitis. Patientswith atopic dermatitis, chronic spontaneous urticaria, allergic contactdermatitis, prurigo nodularis, primary cutaneous lymphoma and mastocytosisexhibit increased serum levels of IL-31 protein and elevated IL-31 mRNA in theskin.
Reference:
1. J Allergy Clin Immunol. 2023 Jul13;S0091-6749(23)00888-6. doi: 10.1016/j.jaci.2023.06.023. Online ahead ofprint.2. Allergy. 2023 Jul 13. doi: 10.1111/all.15816.Online ahead of print.3. Clin Exp Med. 2023 Jul 1. doi:10.1007/s10238-023-01125-x. Online ahead of print.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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