Name:
LILRA4 Protein
Synonyms:
CD85 antigen-like family member G, Immunoglobulin-like transcript 7, ILT7
Species Name:
Human
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
P59901-1
Gene Id:
Glu24-Asn446, with C-terminal 8*HisENLLKPILWAEPGPVITWHNPVTIWCQGTLEAQGYRLDKEGNSMSRHILKTLESENKVKLSIPSMMWEHAGRYHCYYQSPAGWSEPSDPLELVVTAYSRPTLSALPSPVVTSGVNVTLRCASRLGLGRFTLIEEGDHRLSWTLNSHQHNHGKFQALFPMGPLTFSNRGTFRCYGYENNTPYVWSEPSDPLQLLVSGVSRKPSLLTLQGPVVTPGENLTLQCGSDVGYIRYTLYKEGADGLPQRPGRQPQAGLSQANFTLSPVSRSYGGQYRCYGAHNVSSEWSAPSDPLDILIAGQISDRPSLSVQPGPTVTSGEKVTLLCQSWDPMFTFLLTKEGAAHPPLRLRSMYGAHKYQAEFPMSPVTSAHAGTYRCYGSRSSNPYLLSHPSEPLELVVSGATETLNPAQKKSDSKTAPHLQDYTVENGGGSHHHHHHHH
Molecular Weight:
64-73kDa
Purity:
>95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
LILRA4 (also known as ILT7 and CD85g) encodes a preprotein of 499 amino acids that gives rise to a surface receptor with four extracellular immunoglobulin domains, a transmembrane domain, and a short intracellular tail. The human LILR family of immunoreceptors is found on NK cells, T cells, monocytes, B cells, and dendritic cells. LILRA4 is a negative regulatory receptor that is found on resting pDCs and strongly downregulated after viral or bacterial stimulation. LILRA4 protein directly binds to and can be activated by bone marrow stromal cell antigen 2 (BST2; CD317) protein, the expression of which is found on cells preexposed to IFN or on the surface of human cancer cells. The interaction between ILT7 and BST2 functions to assure an appropriate TLR response by pDCs during viral infection and likely participates in pDC-tumor crosstalk.
Reference:
1.Wei Cao, Laura Bover. Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells. Immunol Rev. 2010 Mar;234(1):163-76. doi: 10.1111/j.0105-2896.2009.00867.x.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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