Name:
USP47 Protein
Synonyms:
TRFP
Species Name:
Human
Label Name:
No Tag
Marker Name:
Unconjugated
Accession:
Q96K76
Gene Id:
Met1-Leu157MVPGEENQLVPKEDVFWRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVNERITLNLPASTPVRKLFEDVANKVGYINGTFDLVWGNGINTADMAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEQPQILLEDSSAGEDSVHDRFIGPL
Molecular Weight:
15kDa
Purity:
＞95% by SDS-PAGE&RP-HPLC
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.
Buffer System:
20mM Tris, 200mM NaCl, pH8.0
Quality Statement:
Ubiquitin-specific peptidase 47 (USP47) is a member of the USP subfamily of DUBs. Similaring to other USPs, USP47 regulates cellular activities by removing ubiquitin conjugates from diverse substrates and, thereby, altering their stabilities, localizations, or activities. Specifically, USP47 deubiquitinates and stabilizes MAPK, DNA polymerase β (Polβ), E-cadherin, β catenin, SNAIL, YAP, β-Trcp, and katanin-p60. Hence, USP47 is involved in cell proliferation, cell survival, DNA damage repair, NLRP3 inflammasome activation, and epithelial-mesenchymal transition. USP47 plays an important role in cancers such as gastric cancer, medulloblastoma, and colorectal cancer.
Reference:
1.\tHu Lei, Han-Zhang Xu, Hui-Zhuang Shan, Meng Liu, Ying Lu, Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia. Nat Commun. 2021 Jan 4; 12(1):51. doi: 10.1038/s41467-020-20259-0.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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