CD200 Protein

Quality Statement:
CD200 is a type-1cell membrane glycoprotein of the immunoglobulin supergene family, present onboth cells with myeloid/lymphoid origin as well as on epithelial cells and manycancer cells. CD200, also known as MRC OX-2, is a highly conserved, 48 kDa type1a transmembrane glycoprotein related structurally to the B7 family ofcostimulatory receptors.The molecule itself consists of an IgSF extracellulardomain (single V + C), a single transmembrane region and a short cytoplasmictail lacking signaling motifs. The molecule is expressed by resting dendriticcells, thymocytes, endothelial cells, neurons and osteoblast precursors (OBp),as well as by activated B and T cells (including αβTCR+ and most γδTCR+ cells). CD200 interacts with a structurally relatedreceptor (CD200R) expressed mainly on myeloid cells and is involved inregulation of macrophage and mast cell function. OX-2 / CD200 and CD200R associate via theirrespective N-terminal Ig-like domains. CD200 also plays an important role in prevention of graft rejection,autoimmune diseases and spontaneous abortion.

Reference:
1.Barclay A.N., Wright G.J., Brooke G., Brown M.H.CD200 and membrane protein interactions in the control of myeloid cells. TrendsImmunol. 2002;23:285–290. doi: 10.1016/S1471-4906(02)02223-8. 2.Wright G.J., Puklavec M.J., Willis A.C., HoekR.M., Sedgwick J.D., Brown M.H., Barclay A.N. Lymphoid/Neuronal cell surfaceOX2 glycoprotein recognizes a novel receptor on macrophages implicated in thecontrol of their function. Immunity. 2000;13:233–242. doi: 10.1016/S1074-7613(00)00023-6.3.Moreaux J., Veyrune J.L., Reme T., De Vos J.,Klein B. CD200, A putative therapeutic target in cancer. Biochem. Biophys. Res.Commun. 2008;366:117–122. doi: 10.1016/j.bbrc.2007.11.103. 4.Barclay A.N. Different reticular elements in ratlymphoid tissue identified by localization of IA, Thy-1 and MRC OX-2 antigens.Immunology. 1981;44:727–736.