Name:
BTNL2 Protein
Synonyms:
BTL-II; Butyrophilin like 2; butyrophilin-like 2 (MHC class II associated); Butyrophilin-like 2
Species Name:
Mouse
Label Name:
Mouse Fc Tag
Marker Name:
Unconjugated
Accession:
O70355
Gene Id:
Lys24-Trp454, with C-terminal Mouse mIgG2a FcKHPDDFRVVGPNLPILAKVGEDALLTCQLLPKRTTAHMEVRWYRSDPDMPVIMYRDGAEVTGLPMEGYGGRAEWMEDSTEEGSVALKIRQVQPSDDGQYWCRFQEGDYWRETSVLLQVAALGSSPNIHVEGLGEGEVQLVCTSRGWFPEPEVHWEGIWGEKLMSFSENHVPGEDGLFYVEDTLMVRNDSVETISCFIYSHGLRETQEATIALSERLQTELASVSVIGHSQPSPVQVGENIELTCHLSPQTDAQNLEVRWLRSRYYPAVHVYANGTHVAGEQMVEYKGRTSLVTDAIHEGKLTLQIHNARTSDEGQYRCLFGKDGVYQEARVDVQVMAVGSTPRITREVLKDGGMQLRCTSDGWFPRPHVQWRDRDGKTMPSFSEAFQQGSQELFQVETLLLVTNGSMVNVTCSISLPLGQEKTARFPLSGWIEGRMDPEPRGPTIKPCPPCKCPAPNLLGGPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEEEMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSRTPGK
Molecular Weight:
72-95kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
Butyrophilin-like 2(BTNL2) is a member of the BTN/MOG Ig-superfamily and functions as a negativeregulator of immune cell activation.BTNL2 is expressed in epithelial cells ofthe small intestine, colonic dendritic cells, and in cells of the lymph node.BTNL2 expression is upregulated in T cells following activation, acharacteristic BTNL2 shares with the homologous B7 family of co-stimulatorymolecules. BTNL2 negatively regulates T cells by inhibiting proliferation andinflammatory cytokine secretion. It also increases the expression of FoxP3 in Tcells to promote regulatory T cell development. Single nucleotide polymorphismsin BTNL2 are associated with a risk for sporadic prostate cancer, rheumatoidarthritis, sarcoidosis, ulcerative colitis, and other inflammatory diseases.
Reference:
1.Arnett, H.A. et al. (2007) J. Immunol. 178:1523.2.Arnett, H.A. et al. (2009) Cytokine 46:370.3.Smith, I.A. et al. (2010) J. Immunol. 184:3514.4.Nguyen, T. et al. (2006) J. Immunol. 176:7354.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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