Name:
Biotinylated Her2 Protein
Synonyms:
CD340, ERBB2, NEU, NGL, MLN19, TKR1
Species Name:
Human
Label Name:
Avi Tag, His Tag
Marker Name:
Biotin
Accession:
P04626-1
Gene Id:
Thr23-Thr652, with C-terminal 8*His & Avi tagTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTGGGSHHHHHHHHGLNDIFEAQKIEWHE
Molecular Weight:
80-95kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
· 12months from date of receipt, -20 to -70 °C as supplied. · 6months, -20 to -70 °C under sterile conditions after reconstitution.· 1week, 2 to 8 °C under sterile conditions after reconstitution.·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
Human Epidermal growth factor Receptor 2(HER2) is also called ERBB2, HER-2, HER-2 /neu, NEU, NGL, TKR1 and c-erb B2,and is a protein giving higher aggressiveness in breast cancers. It is a memberof the ErbB protein family, more commonly known as the epidermal growth factorreceptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinaseand is normally involved in the signal transduction pathways leading to cellgrowth and differentiation. Human ErbB2 consists of 1255 amino acids (aa)including a 22 aa signal sequence, a 630 aa extracellular domain (ECD), a 23 aatransmembrane region, and a 580 aa cytoplasmic domain. HER2 appears to playroles in development, cancer, communication at the neuromuscular junction andregulation of cell growth and differentiation. Phosphoinositide 3-kinase hasbeen shown to play a role in ErbB2 signal transduction. The cytoplasmic domainof ErbB2 has been shown to associate with beta-catenin and plakoglobin.
Reference:
1.Antonio C. Wolff; M. Elizabeth H. Hammond; JaredN. Schwartz; Karen L. Hagerty; D. Craig Allred; Richard J. Cote; MitchellDowsett; Patrick L. Fitzgibbons; Wedad M. Hanna; Amy Langer; Lisa M. McShane;Soonmyung Paik; Mark D. Pegram; Edith A. Perez; Michael F. Press; AnthonyRhodes; Catharine Sturgeon; Sheila E. Taube; Raymond Tubbs; Gail H. Vance; Marcvan de Vijver; Thomas M. Wheeler; Daniel F. Hayes: American Society of ClinicalOncology/College of American Pathologists Guideline Recommendations for HumanEpidermal Growth Factor Receptor 2 Testing in Breast Cancer, Arch Pathol Lab Med (2007) 131 (1): 18–43.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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