Name:
Biotinylated B7-2 Protein
Synonyms:
CD28LG2, B7-2, CD86, B70, LAB72, MGC34413
Species Name:
Human
Label Name:
Human Fc Tag, Avi Tag
Marker Name:
Biotin
Accession:
P42081
Gene Id:
Leu26-Pro247, with C-terminal Human IgG1 Fc &AvitagLKIQAYFNETADLPCQFANSQNQSLSELVVFWQDQENLVLNEVYLGKEKFDSVHSKYMGRTSFDSDSWTLRLHNLQIKDKGLYQCIIHHKKPTGMIRIHQMNSELSVLANFSQPEIVPISNITENVYINLTCSSIHGYPEPKKMSVLLRTKNSTIEYDGVMQKSQDNVTELYDVSISLSVSFPDVTSNMTIFCILETDKTRLLSSPFSIELEDPQPPPDHIPIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGLNDIFEAQKIEWHE
Molecular Weight:
72-85kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
· 12months from date of receipt, -20 to -70 °C as supplied. · 6months, -20 to -70 °C under sterile conditions after reconstitution.· 1week, 2 to 8 °C under sterile conditions after reconstitution.·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
CD86 is a well-known costimulatory molecule inits interaction with CD28 and/or CTLA present on T cells, and is essential forfull activation of naive T-cell and subsequent differentiation. Usually, the B7molecules are expressed mainly on APCs and B cells and in specific conditionson other activated cells. These costimulatory molecules are involved in thedevelopment of allergic inflammation and airways hyperreactivity (AHR) inallergen-challenged mice. Activated T cells, CD4+CD25+, express CD86 in the first60 minutes after the specific inhalation exposure. These T cells can berelevant in IgE mediated allergic reaction possibly by an autocrineco-stimulation via CD28/CTLA activation pathway. The blockage of the expressionof CD86 could be a potential therapeutical target to reduce the magnitude orthe progression of the allergic reaction.
Reference:
1.Chia-Lin Chen, Jeffrey Y. Huang, Chun-HsiangWang, Stanley M Tahara, Lin Zhou, Yasuteru Kondo, Joel Schechter, Lishan Su,Michael M C. Lai, Takaji Wakita, François-Loïc Cosset, Jae U Jung & KeigoMachida: Hepatitis C virus has a genetically determined lymphotropism throughco-receptor B7.2, NatureCommunications volume 8, Article number: 13882 (2017).
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
TGF beta 3/TGFB3 Protein
SIAE Protein
Popular categories:
DEP-1 Proteins
FCGR2A/CD32a
