Name:
OPN/SPP1 Protein
Synonyms:
BNSP, BSP-1
Species Name:
Human
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
P10451-5
Gene Id:
Ile17-Asn300, with C-terminal 8*His IPVKQADSGSSEEKQLYNKYPDAVATWLNPDPSQKQNLLAPQTLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSHEFHSHEDMLVVDPKSKEEDKHLKFRISHELDSASSEVNGGGSHHHHHHHH
Molecular Weight:
45-55kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
· 12months from date of receipt, -20 to -70 °C as supplied. · 6months, -20 to -70 °C under sterile conditions after reconstitution.· 1week, 2 to 8 °C under sterile conditions after reconstitution.·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
OPN is an integrin-binding glycoprotein alsoknown as secreted phosphoprotein 1 (SPP1). OPN is so named because it was firstdiscovered in osteoblasts and osteoclasts. The latter is developed from themacrophage lineage. OPN protein has a secreted form and an intracellular form.The secreted OPN has two integrin-binding domains which can adhere to integrinson the surfaces of macrophages, making it a potent chemoattractant as well asan activator of macrophages. In innate immunological cells such as dendriticcells, OPN can be activated upon infection. The OPN-integrin binding cantrigger downstream macrophage activities including TNF secretion, producing aninflammatory microenvironment. Poor prognosis of HCC was correlated withelevated OPN RNA, tissue OPN protein levels and pre-operative serum OPN proteinlevels. An anti-OPN antibody has been shown to defer the growth and metastasisof breast cancer in a mice model. As macrophages can also secret OPN, PTM andOPN form a vicious autocrine/paracrine cycle for the progression of cancer.Thus, in the future, novel strategies to break this cycle could bring to newanti-HCC treatments.
Reference:
1. Kung-Hao Liang. OPN sesame. Hepatobiliary Surg Nutr 2014;3(3):112-114.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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