Name:
Galectin-9 Protein
Synonyms:
Gal-9, Ecalectin, Tumor antigen HOM-HD-21
Species Name:
Human
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
O00182-2
Gene Id:
Ala2-Thr323, with N-terminal 8* HisHHHHHHHHAFSGSQAPYLSPAVPFSGTIQGGLQDGLQITVNGTVLSSSGTRFAVNFQTGFSGNDIAFHFNPRFEDGGYVVCNTRQNGSWGPEERKTHMPFQKGMPFDLCFLVQSSDFKVMVNGILFVQYFHRVPFHRVDTISVNGSVQLSYISFQPPGVWPANPAPITQTVIHTVQSAPGQMFSTPAIPPMMYPHPAYPMPFITTILGGLYPSKSILLSGTVLPSAQRFHINLCSGNHIAFHLNPRFDENAVVRNTQIDNSWGSEERSLPRKMPFVRGQSFSVWILCEAHCLKVAVDGQHLFEYYHRLRNLPTINRLEVGGDIQLTHVQT
Molecular Weight:
47-55kDa (Reducing)
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
·12 months from date of receipt, -20 to -70 °C as supplied. ·1 month, 2 to 8 °C under sterile conditions after reconstitution. ·Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
Galectin-9 is a β-galactoside binding lectinknown for its immunomodulatory role in various microbial infections. Gal-9 isexpressed in all organ systems and localized in the nucleus, cell surface,cytoplasm and the extracellular matrix. Gal-9 structurally consists of twohomologous carbohydrate-recognition domains at the N- and C-terminus (NCRD andCCRD, respectively) linked by a linker peptide that is highly susceptible toproteolysis. It mediates host-pathogen interactions and regulates cellsignalling via binding to its receptors. Gal-9 is involved in manyphysiological functions such as cell growth, differentiation, adhesion,communication and death. Gal-9 is a molecule that positively and negativelyadjusts immune systems as both a contributing factor in cytokine storm and animmunosuppressive molecule inducing, for instance, T-cell exhaustion andapoptosis.
Reference:
1.Iwasaki-Hozumi H., Chagan-Yasutan H., Ashino Y., Hattori T. Blood Levelsof Galectin-9, an Immuno-Regulating Molecule, Reflect the Severity for theAcute and Chronic Infectious Diseases. Biomolecules. 2021;11:430. 2.Nishi N., Itoh A., Fujiyama A., Yoshida N., Araya S.-i., Hirashima M.,Shoji H., Nakamura T. Development of highly stable galectins: Truncation of thelinker peptide confers protease-resistance on tandem-repeat type galectins.FEBS Lett. 2005;579:2058–2064. 3.Oomizu S., Arikawa T., Niki T., Kadowaki T., Ueno M., Nishi N., Yamauchi A., HirashimaM. Galectin-9 suppresses Th17 cell development in an IL-2-dependent butTim-3-independent manner. Clin. Immunol. 2012;143:51–58. d4.Bozorgmehr N., Mashhouri S., Perez Rosero E., Xu L., Shahbaz S., Sligl W.,Osman M., Kutsogiannis D.J., MacIntyre E., O’Neil C.R., et al. Galectin-9, aPlayer in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker inSARS-CoV-2 Infection. mBio. 2021;12:e00384-21.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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