Name:
Nectin-4 Protein
Synonyms:
PVRL4; Nectin-4; Ig superfamily receptor LNIR; Poliovirus receptor-related protein 4; PRR4; LNIR; Nectin4
Species Name:
Human
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
Q96NY8-1
Gene Id:
Q96NY8-1, Gly32-Ser349, with C-8*His\rGELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASGGGSGGGSHHHHHHHH
Molecular Weight:
44-47 kDa(reducing)
Purity:
＞95%, by SDS-PAGE under reducing conditions
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
· 12 months from date of receipt, -20 to -70 °C as supplied. · 6 months, -20 to -70 °C under sterile conditions after reconstitution.· 1 week, 2 to 8 °C under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
Nectin-4, also known as poliovirus-like receptor 4 (PVRL4), is a newly discovered cell adhesion molecule, which belongs to the Nectin family. There are four members of the Nectin family: Nectin-1, Nectin-2, Nectin-3 and Nectin-4. There are three continuous immunoglobulin-like domains outside the cells of Nectin protein, which are N-terminal Ig-V domain and C-terminal Ig-C2 domain. Nectin-4 is mainly expressed in placenta, expressed in normal human tissues including skin, bladder, salivary glands, esophagus, breast and stomach, and abnormally expressed on the surface of a variety of cancer cells such as breast cancer, bladder cancer, non-small cell lung cancer and pancreatic cancer. Nectin-4 promotes the proliferation, differentiation, migration and invasion of tumor cells by activating PI3K/Akt pathway. In some cancers, such as urothelial carcinoma, the high expression of Nectin-4 can promote tumor cell proliferation and angiogenesis and reduce cancer cell apoptosis. Some studies have shown that Nectin-4, as a new ligand of TIGIT, can inhibit the activity of natural killer cells. These suggest that Nectin-4 may be a potential target for cancer therapy.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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