Name:
FGF-12 Protein
Synonyms:
Fibroblast growth factor homologous (FHF-1), Myocyte-activating factor, \tFGF12B
Species Name:
Human
Label Name:
No Tag
Marker Name:
Unconjugated
Accession:
P61328-2
Gene Id:
Met1-Thr181 MESKEPQLKGIVTRLFSQQGYFLQMHPDGTIDGTKDENSDYTLFNLIPVGLRVVAIQGVKASLYVAMNGEGYLYSSDVFTPECKFKESVFENYYVIYSSTLYRQQESGRAWFLGLNKEGQIMKGNRV
Molecular Weight:
21kDa
Purity:
＞95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.
Buffer System:
20mM PB, 150mM NaCl, 1mM DTT, 1mM EDTA, pH 7.4
Quality Statement:
Fibroblast growth factor 12 (FGF-12), also known as fibroblast growth factor homologous factors (FHF), is cytosolic proteins that is homologous to fibroblast growth factors but is not secreted. FGF12 modulates both cardiac Na+ and Ca+ channel by binding to the conserved proximal part of the C-terminal domain of voltage-gated sodium channels Nav1.5. However, a single missense mutation in FGF12-B (Q7R-FGF12) reduced binding to the NaV1.5 C-terminus, yielding a Brugada Syndrome phenotype.
Reference:
1.\tAm J Physiol Heart Circ Physiol. 2015 Jun 15;308(12):H1463-73.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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