Name:
IL-2R beta/CD122 Protein
Synonyms:
IL-2R beta, CD122, IL2RB, RP5-1170K4.6, P70-75
Species Name:
Human
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
P14784
Gene Id:
Ala27-Asp239, with C-terminal 8*His AVNGTSQFTCFYNSRANISCVWSQDGALQDTSCQVHAWPDRRRWNQTCELLPVSQASWACNLILGAPDSQKLTTVDIVTLRVLCREGVRWRVMAIQDFKPFENLRLMAPISLQVVHVETHRCNISWEISQASHYFERHLEFEARTLSPGHTWEEAPLLTLKQKQEWICLETLTPDTQYEFQVRVKPLQGEFTTWSPWSQPLAFRTKPAALGKDGGGSHHHHHHHH
Molecular Weight:
36-42kDa
Purity:
>95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
Interleukin-2 receptor (IL-2R), as the specific receptor of interleukin-2(IL-2), perform their biological functions by binding with IL-2 to transmit signals into cells insides, which induced the downstream signal expression and participated in immune response. The longest IL-2R beta (IL-2Rβ) in the intracellular region has many binding sites for protein phosphorylation. Therefore, IL-2Rβ plays an indispensable role in signal transduction due to its sequence and structural characteristics. IL-2R mediates the multipotency of IL-2 on AC lymphocytes including T cells, B cells and NK cells. The combination of IL-2 and IL-2R complex can cause intracellular signal events and ultimately lead to cell proliferation. In addition, dysregulated expression of the IL-2Rβ abrogates development of NK cells. What’s more important is that T cell proliferation and development of IFNc-producing effector CD8+ T cells depend upon IL-2Rβ.
Reference:
1、Foss F. (2006) Clinical experience with denileukin diftitox (ONTAK). Semin Oncol. 33(1 Suppl 3): 11-6.2、Sprent J. et al. (2001) T cell death and memory. Science. 293(5528): 245-248.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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