Name:
PILRα Protein
Synonyms:
PILRα, PILRA, FDF03, AV021745
Species Name:
Human
Label Name:
His Tag
Marker Name:
Unconjugated
Accession:
Q9UKJ1-1
Gene Id:
Gln20-Thr196, with C-terminal 8*HisQPSGSTGSGPSYLYGVTQPKHLSASMGGSVEIPFSFYYPWELATAPDVRISWRRGHFHRQSFYSTRPPSIHKDYVNRLFLNWTEGQKSGFLRISNLQKQDQSVYFCRVELDTRSSGRQQWQSIEGTKLSITQAVTTTTQRPSSMTTTWRLSSTTTTTGLRVTQGKRRSDSWHISLETGGGSHHHHHHHH
Molecular Weight:
41-47kDa
Purity:
>95% by SDS-PAGE
Physical Appearance Name:
Lyophilized Powder
Endotoxin Name:
<0.1EU/μg
Reconstitution:
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability Storage:
12 months from date of receipt, -20 to -70 °C as supplied; 6 months, -20 to -70 °C under sterile conditions after reconstitution; 1 week, 2 to 8 °C under sterile conditions after reconstitution; Please avoid repeated freeze-thaw cycles.
Buffer System:
PBS, pH7.4
Quality Statement:
Paired immunoglobulin-like type 2 receptor α (PILRα) is an inhibitory receptor that is mainly expressed on macrophages, dendritic cells and granulocytes, and negatively regulates neutrophil infiltration during inflammation. PILRα containing two immunoreceptor tyrosine-based inhibitory motifs in the intracellular domain, which recruit Src homology region 2 domain-containing phosphatase (SHP)-1 and -2. Reported that PILRα associates with several ligands, including CD99, PILR-associating neural protein, neuronal differentiation proliferation factor-1, and collectin-12, and PILRα plays an important role in viral infections. Neutrophil recruitment in inflammatory responses is regulated by PILRα via modulation of integrin activation. Furthermore, negative regulation of inflammatory arthritis by PILRα has been reported.
Reference:
1、Shiratori I. et al. (2004) Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor. J Exp Med. 199: 525-533.2、Satoh T. et al. (2008) PILRα is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B. Cell. 132: 935-944.3、Wang J. et al. (2013) Neutrophilin filtration during inflammation is regulated by PILRαvia modulation ofintegrin activation. Nat Immunol. 14: 34-40.4、Sun Y. et al. (2014) PILRα negatively regulates mouse inflammatoryarthritis. J Immunol. 193: 860-870.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
IL-23 alpha (175a.a) & IL-12 beta (313a.a) Heterodimer Protein
APOC2 Protein
Popular categories:
Complement Factor H Related 3
PTPN2
