ten, x FOR PEER Overview six (SE) plasma ofducks; (I)The ratemeans p 0.01.Values imply the mean SEM (regular errorof 19 of suggests.), implies p 0.05, of AST/ALT. signifies.), indicates p 0.05, means p 0.01.three.two. Evaluation of Pathological Sections and Ultrastructural Assessment in Liver Histopathological examination of H E-stained livers shown in Bim MedChemExpress Figure 2. Inside the T0 group, hepatocytes morphology was standard (Figure 2A). AFB1 administration triggered clear toxicity containing vacuolation of hepatocytes, swelling of hepatocytes, and inflammatory cell infiltration within the T0 + AFB1 group in comparison with the T0 group (Figure 2B). Dietary curcumin protected the liver against harm by means of the reduce in the number of inflammatory cells and swelling of hepatocytes within the liver of ducks inside the T500 + AFB1 group compared with in the T0 + AFB1 group (Figure 2C). A few inflammatory cells and swelling of hepatocytes within the T500 + AFB1 group compared with all the T0 group was noticed. The outcomes of this study demonstrate that dietary curcumin could safeguard duck liver against acute harm induced by AFB1 administration. The liver ultrastructure is shown in Figure 2. In the T0 group, the cell nucleus and mitochondrial ridge of hepatocytes have been clearly visible as well as the chromatin within the cell nucleus was evenly distributed (Figure 2D). In comparison together with the T0 group, the hepatocyte nucleus was Aurora A web visibly deformed; chromatin was aggregated as well as the hepatocyte mitochondrial ridge was enlarged and deformed within the T0 + AFB1 group (Figure 2E). As anticipated, in comparison with all the T0 + AFB1 group, hepatocyte nucleus and mitochondrial ridge had been AFB1 visible along with the group Figure 2. Histopathological and ultrastructure examination in liver of ducks exposed clearlyat 12 h. (A): controlchromatin agFigure 2. Histopathological and ultrastructure examination in liver of ducks exposed toto AFB1 at 12 h. (A): manage group (T0), (B): AFB1 group (T0 + gregation of hepatocytes was observed inside the Tcontrol group (T0), (E): AFB1 group (Taddition, AFB1); (C): curcumin + AFB1 group (T500 + AFB1); (D): 500 + AFB1 group (Figure 2F). In 0 (T0 ), (B): AFB1 group (T0 + AFB1); (C): curcumin + AFB1 group (T500 + AFB1); (D): control group (T0 ), (E): AFB1 group (T0 the hepatocyte nucleus blue arrowheads indicate swollen of liver cells, the red arrowheads + AFB1); (F): curcumin + AFB1 group (T500 + AFB1). Theand mitochondrial ridge had been clearly visible when comparing the + AFB1); (F): curcumin + AFB1 group (T500 + AFB1). The blue arrowheads indicate aggregation, plus the pinkred arrowheads swollen of liver cells, the arrowheads indicate inflammatory cell T500 + AFB1 group and T0 group. infiltration, the white arrowheads indicate chromatinindicate inflammatory cell on the cell nucleus. indicate the morphology infiltration, the white arrowheads indicate chromatin aggregation, and the pink arrowheads indicate the morphology in the cell nucleus.Foods 2021, ten, x FOR PEER REVIEWFoods 2021, 10,7 of6 of3.three. CYP450 Content in Liver three.three. CYP450 Content material in Liver Adjustments in CYP450 content material in ten liver homogenate are shown in Figure three. There Changes in CYP450 content in ten liver homogenate are shown in Figure three. There was aasignificant raise in CYP450 (p = 0.008) content within the T00++ AFB1 group relative was substantial raise in CYP450 (p = 0.008) content within the T AFB1 group relative to to that inside the T0 group. Dietary curcumin supplementation significantly attenuated the that in the T0 group. Dietary curcumin su
