Oodness-of-fit (GOF) diagnostic plots are shown in Figure 2. The popu4 of
Oodness-of-fit (GOF) diagnostic plots are shown in Figure two. The popu4 of 11 four of 12 lation prediction concentrations (PRED) and individual prediction concentrations (IPRED) depending on the final model corresponded properly with the observed concentrations and they were evenly distributed on each sides of your reference line (Y = X). The conditional Methyl jasmonate Autophagy weighted residuals (CWRES) values have been distributed within the array of , indicating the model Moveltipril Metabolic Enzyme/Protease fitted nicely. The numerical predictive check (NPC) benefits are shown in Table three. Taking the 90 prediction interval as an instance, seven observations (five.34 ) have been below the 5th percentile and inside the corresponding 95 self-assurance interval (0.762.98 ). Nine observations (six.87 ) were above the 95th percentile and within their 95 self-confidence interval (0.002.98 ). In total, 12.21 of your observations had been outside the 90 prediction range, which was close towards the anticipated value of 10 , indicating that the prediction performance in the model was properly. Figure 1. Two compartment model of vancomycin for critically ill sufferers undergoing CVVH.Figure 1. Two compartment model of vancomycin for critically ill patients undergoing CVVH.2.two.3. Model Evaluation The common goodness-of-fit (GOF) diagnostic plots are shown in Figure two. The population prediction concentrations (PRED) and individual prediction concentrations (IPRED) based on the final model corresponded well with the observed concentrations and they were evenly distributed on both sides with the reference line (Y = X). The conditional weighted residuals (CWRES) values have been distributed inside the selection of , indicating the model fitted properly. The numerical predictive verify (NPC) results are shown in Table 3. Taking the 90 prediction interval as an example, seven observations (5.34 ) had been under the 5th percentile and inside the corresponding 95 self-confidence interval (0.762.98 ). Nine observations (6.87 ) were above the 95th percentile and within their 95 confidence interval (0.002.98 ). In total, 12.21 of the observations had been outside the 90 prediction variety, which was close to the anticipated worth of 10 , indicating that the prediction overall performance with the model was well.Figure two. The typical goodness-of-fit diagnostic plots on the final model were as follows: individFigure 2. The typical goodness-of-fit diagnostic plots from the final model were as follows: individual ual prediction concentrations (IPRED) versus observed vancomycin plasma concentrations (DV) prediction concentrations (IPRED) versus observed vancomycin plasma concentrations (DV) (top (prime left), population prediction concentrations (PRED) versus observed vancomycin plasma concentrations (leading proper), conditional weighted residuals (CWRES) versus population prediction (PRED) concentrations (bottom left), and conditional weighted residuals versus time soon after dose (TIME) (bottom appropriate). The diagonal lines inside the upper panels represent lines of unity.The numerical predictive check (NPC) outcomes are shown in Table 3. Taking the 90 prediction interval as an instance, seven observations (five.34 ) were below the 5th percentile and inside the corresponding 95 self-confidence interval (0.762.98 ). Nine observations (6.87 ) had been above the 95th percentile and inside their 95 self-assurance interval (0.002.98 ). In total, 12.21 with the observations were outside the 90 prediction range, which was close to the expected value of 10 , indicating that the prediction overall performance on the model was well. 2.3. Population PK/PD AnalysisFigure.
