Omania; [email protected] Academy of Romanian Scientists, 3 Ilfov Street, 050045 Bucharest, Romania Correspondence: [email protected]: Spoial , A.; Ilie, C.-I.; a Cr ciun, L.N.; Ficai, D.; Ficai, A.; a Andronescu, E. Magnetite-Silica Core/Shell Nanostructures: From Surface Functionalization towards Biomedical Applications–A Overview. Appl. Sci. 2021, 11, 11075. https:// doi.org/10.3390/app112211075 Academic Editors: Pietro Calandra and Domenico Lombardo Received: 11 September 2021 Accepted: 19 November 2021 Published: 22 Safranin In Vivo NovemberFeatured Application: The magnetic core is often utilized in targeting but additionally in magnetic actuation even though silica can have numerous function: compatibilizing agent, UCB-5307 supplier protecting agent even in harsh circumstances, drug reservoir or adsorbent, and so forth. Therefore, magnetite-silica core/shell nanostructures is usually utilized in many applications such as development of drug delivery systems, contrast agent, certain adsorbent, filler in various polymers, magnetic micro devices, and so on. Abstract: The interconnection of nanotechnology and medicine could bring about improved components, offering a much better top quality of life and new opportunities for biomedical applications, moving from analysis to clinical applications. Magnetite nanoparticles are interesting magnetic nanomaterials because on the property-depending approaches chosen for their synthesis. Magnetite nanoparticles could be coated with several components, resulting in “core/shell” magnetic structures with tunable properties. To synthesize promising components with promising implications for biomedical applications, the researchers functionalized magnetite nanoparticles with silica and, thanks to the presence of silanol groups, the functionality, biocompatibility, and hydrophilicity were improved. This review highlights probably the most vital synthesis methods for silica-coated with magnetite nanoparticles. From the presented approaches, the most used was the St er approach; you will find also other syntheses presented in the review, for example co-precipitation, sol-gel, thermal decomposition, and the hydrothermal system. The second portion in the review presents the key applications of magnetite-silica core/shell nanostructures. Magnetite-silica core/shell nanostructures have promising biomedical applications in magnetic resonance imaging (MRI) as a contrast agent, hyperthermia, drug delivery systems, and selective cancer therapy but also in developing magnetic micro devices. Keywords and phrases: magnetite-silica; core/shell nanostructures; biomedical applicationPublisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.Copyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This short article is an open access post distributed under the terms and conditions on the Inventive Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ four.0/).1. Introduction Nanotechnology and nanoscience involve the capability to manipulate matter with no less than a dimension among 1 and one hundred nanometers being associated with imaging, measure, and model, but also to the improvement of materials and applications by exploring their special properties exposed at the nanometric scale [1]. More than the previous decade, nanotechnology has been integrated into medicine and biology by establishing a brand new active and important research region, nanomedicine, whichAppl. Sci. 2021, 11, 11075. https://doi.org/10.3390/apphttps://www.mdpi.com/journal/applsciAppl. Sci. 2021, 11,.
