Cts and purified chemical substances of nutritional interest from both herbal
Cts and purified chemical substances of nutritional interest from both herbal and animal origin is attracting increasing attention among clinical and basic science investigators (e.g., [19, 93]). An expanding focus of this research is aimed at PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/27324125 elucidating the mechanism of action of “natural compounds” and the presumed consequences for metabolic health. Segments of the non-scientific community, and in particular the media, avidly follow the developments of this research field. The phenomenological/ethno-medical field has contributed observational and anecdotal results stimulating researchers to propose robust, science-based mechanisms of action. In particular, the definition of key molecular pathways affected by phytochemical and nutritional bioactive compounds is of crucial importance to understand health effects. Unfortunately, research in this area often lacked rigor, reproducibility, and molecular detail, and its outcomes were therefore received with justifiable skepticism. G N publishes original research papers and reviews dealing with bioactive constituents of traditional or novel foods, and of botanical extracts targeted at promoting health and preventing or treating disease. According to our scopes and aims, G N encourages studies of theKaput et al. Genes Nutrition (2017) 12:Page 7 ofeffects of bioactives on the modulation of biochemical pathways, cellular signaling, and gene expression. In line with our quest for standardization, studies dealing with the effects of natural compounds or food/botanical extracts should report a complete characterization and standardization of the compound/ s under study, to allow reproducibility. Exceptions to this guideline may be possible with very strong evidence of the importance of their results or when dealing with novel botanical extracts of extreme interest, whose effects have never been reported in the available literature, and for which chemical characterization is in progress.Summary Reproducibility, or at least the ability to understand the reasons for different results and outcomes in preclinical and clinical research experiments, is now demanding the attention of researchers, funding agencies, and the public (e.g., [76]). The intent of this editorial was to provide guidance for improving the quality of systems nutritionTable 3 Summary of genes and nutrition publication guidelines1. Standardization/reproducibility of data and findings. Manuscripts submitted to G N should contain the necessary information allowing evaluation of alignment with widely accepted best practices (see Table 2 for specific guidelines). These standards include descriptions of reference materials and reagents, study design, order Bayer 41-4109 laboratory protocols, data analysis, and reporting. We recommend authors to refer to the MIBBI Portal (Minimum Information for Biological and Biomedical Investigations) for prescriptive checklists for reporting biological and biomedical research where applicable. 2. Gene variants. G N manuscripts reporting associations between single SNPs and complex phenotypes or single SNPs and response to diet will not be sent for peer review unless (i) the effect size is large, (ii) p values significant and corrected for multiple comparison, and (iii) replicated in a second study. Complex phenotypes include diseases, anthropometric measures (e.g., body weight or body mass index), and intermediate risk factors (e.g., levels or changes in fasting blood parameters). 3. Women’s health research. Sexual dimorp.
