Ancer, including gene amplification, transcriptional regulation, and mRNA and protein stabilization, which correlate with loss of tumor suppressors and activation of oncogenic pathways [25]. Title Loaded From File breast cancer has 1317923 been classified into 5 or more subtypes based on gene expression profiles, and each Title Loaded From File subtype has distinct biological features and clinical outcomes. Among these subtypes, basal-like tumor is associated with a poor prognosis and has a lack of therapeutic targets. MYC is overexpressed in the basal-like subtype and may serve as a target for this aggressive subtype of breast cancer. Tumor suppressor BRCA1 inhibits MYC’s transcriptional and transforming activity [25]. Loss of BRCA1 with MYC overexpression leads to the development of breast cancer, especially, basal-like breast cancer. As a downstream effector of estrogen receptor and epidermal growth factor receptor family pathways, MYC may contribute to resistance to adjuvant therapy. Targeting MYC-regulated pathways in combination with inhibitors of other oncogenic pathways may provide a promising therapeutic strategy for breast cancer, the basal-like subtype in particular [26].As far as the model is concerned, there are a few possible weaknesses in the procedure, mainly related to the prior 0 specification for parameters dg s , related to differential expression and prediction. We were dealing with highly parametrized models and few observations data sets, reason why we chose some easier shortcuts in order to achieve faster 1315463 MCMC convergency. Some interesting modifications of our prior specifications are now to be implemented, since we found in literature new and more efficient approaches to the issue of sparsity, such as the horseshoe prior [27]. Also, it was very hard to compare our models’ performances with other methods, either due to the lack of codes or to the scarcity of works on the specific topic of prediction using integrated genomic platforms; we therefore chose a simple LASSO logistic regression which showed to be a poor fit for this particular data and this is mainly due to the high correlation between them. Future work includes the development of models for integration of three or more platforms, and the extension to new type of genomics data, such as next-generation sequencing (NGS) data. In the latter case, the main challenge is the inclusion of a model for the count data from the NGS experiment. The intuitive statistical method for such an extension would be a graphical model, where network priors will be considered treating each platform as a node, and edges among the nodes will be interpreted as dependence between platforms. Finally, all this project was focused on a specific data set, with rather particular features. The natural hierarchical structure and correlation between DNA and RNA makes very hard to think of the application of our methodology to different problems, though an interesting path to follow could be that of demographical sciences, where this hierarchical structure could be found for example in data at country level and regional level.Author ContributionsConceived and designed the experiments: LP YQ TI. Performed the experiments: LP YQ TI. Analyzed the data: FT YJ PM. Wrote the paper: FT.
Dementia is a syndrome characterized by the impairment of cognitive functions, such as memory, language, abstraction, organization, planning, attention, and visuospatial skills [1]. These deficits, which are associated with a decline in the performance of everyday ac.Ancer, including gene amplification, transcriptional regulation, and mRNA and protein stabilization, which correlate with loss of tumor suppressors and activation of oncogenic pathways [25]. Breast cancer has 1317923 been classified into 5 or more subtypes based on gene expression profiles, and each subtype has distinct biological features and clinical outcomes. Among these subtypes, basal-like tumor is associated with a poor prognosis and has a lack of therapeutic targets. MYC is overexpressed in the basal-like subtype and may serve as a target for this aggressive subtype of breast cancer. Tumor suppressor BRCA1 inhibits MYC’s transcriptional and transforming activity [25]. Loss of BRCA1 with MYC overexpression leads to the development of breast cancer, especially, basal-like breast cancer. As a downstream effector of estrogen receptor and epidermal growth factor receptor family pathways, MYC may contribute to resistance to adjuvant therapy. Targeting MYC-regulated pathways in combination with inhibitors of other oncogenic pathways may provide a promising therapeutic strategy for breast cancer, the basal-like subtype in particular [26].As far as the model is concerned, there are a few possible weaknesses in the procedure, mainly related to the prior 0 specification for parameters dg s , related to differential expression and prediction. We were dealing with highly parametrized models and few observations data sets, reason why we chose some easier shortcuts in order to achieve faster 1315463 MCMC convergency. Some interesting modifications of our prior specifications are now to be implemented, since we found in literature new and more efficient approaches to the issue of sparsity, such as the horseshoe prior [27]. Also, it was very hard to compare our models’ performances with other methods, either due to the lack of codes or to the scarcity of works on the specific topic of prediction using integrated genomic platforms; we therefore chose a simple LASSO logistic regression which showed to be a poor fit for this particular data and this is mainly due to the high correlation between them. Future work includes the development of models for integration of three or more platforms, and the extension to new type of genomics data, such as next-generation sequencing (NGS) data. In the latter case, the main challenge is the inclusion of a model for the count data from the NGS experiment. The intuitive statistical method for such an extension would be a graphical model, where network priors will be considered treating each platform as a node, and edges among the nodes will be interpreted as dependence between platforms. Finally, all this project was focused on a specific data set, with rather particular features. The natural hierarchical structure and correlation between DNA and RNA makes very hard to think of the application of our methodology to different problems, though an interesting path to follow could be that of demographical sciences, where this hierarchical structure could be found for example in data at country level and regional level.Author ContributionsConceived and designed the experiments: LP YQ TI. Performed the experiments: LP YQ TI. Analyzed the data: FT YJ PM. Wrote the paper: FT.
Dementia is a syndrome characterized by the impairment of cognitive functions, such as memory, language, abstraction, organization, planning, attention, and visuospatial skills [1]. These deficits, which are associated with a decline in the performance of everyday ac.
