Cle cells. J Mol Cell Cardiol 46: 748 757. 19. Kong X, Fang M, Li P, Fang F, Xu Y HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells. J Mol Cell Cardiol 46: 292299. 20. Xu Y, Luchsinger L, Lucey EC, Smith BD The impact of class II transactivator mutations on bleomycin-induced lung inflammation and fibrosis. American Journal of Respiratory Cell and Molecular Biology 44: 898905. 21. Zhao L, Mason NA, Morrell NW, Kojonazarov B, Sadykov A, et al. Sildenafil inhibits hypoxia-induced pulmonary hypertension. Circulation 104: 424428. 22. Berkenbosch JW, Baribeau J, Perreault T Decreased synthesis and vasodilation to nitric oxide in piglets with hypoxia-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 278: L276283. 23. Vergadi E, Chang MS, Lee C, Liang OD, Liu X, et al. Early macrophage recruitment and option activation are important for the later improvement of hypoxia-induced pulmonary hypertension. Circulation 123: 19861995. 24. Hanaoka M, Kubo K, Yamazaki Y, Miyahara T, Matsuzawa Y, et al. Association of high-altitude pulmonary edema together with the key histocompatibility complex. Circulation 97: 11241128. 25. Steiner MK, Syrkina OL, Kolliputi N, Mark EJ, Hales CA, et al. Interleukin-6 overexpression 256373-96-3 induces pulmonary hypertension. Circ Res 104: 236244, 228p following 244. 26. Chang SW TNF potentiates PAF-induced pulmonary vasoconstriction within the rat: role of neutrophils and thromboxane A2. J Appl Physiol 77: 28172826. 27. Stenmark KR, Davie NJ, Reeves JT, Frid MG Hypoxia, leukocytes, along with the pulmonary circulation. J Appl Physiol 98: 715721. 28. Poiani GJ, Wilson FJ, Fox JD, Sumka JM, Peng BW, et al. Liposomeentrapped antifibrotic agent prevents collagen accumulation in hypertensive pulmonary arteries of rats. Circ Res 70: 912922. 29. Archer SL, Weir EK, Wilkins MR Fundamental science of pulmonary arterial hypertension for clinicians: new ideas and experimental therapies. Circulation 121: 20452066. 30. Chaouat A, Savale L, Chouaid C, Tu L, Sztrymf B, et al. Part for interleukin-6 in COPD-related pulmonary 
hypertension. Chest 136: 678687. 31. Li M, Riddle SR, Frid MG, El Kasmi KC, McKinsey TA, et al. Emergence of fibroblasts using a proinflammatory epigenetically altered phenotype in extreme hypoxic pulmonary hypertension. J Immunol 187: 2711 2722. 32. Oeckinghaus A, Hayden MS, Ghosh S Crosstalk in NF-kappaB signaling pathways. Nat Immunol 12: 695708. 33. Ryan S, Tetracosactide site Taylor CT, McNicholas WT Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome. Circulation 112: 26602667. 34. BelAiba RS, Djordjevic T, Bonello S, Artunc F, Lang F, et al. The serumand glucocorticoid-inducible kinase Sgk-1 is involved in pulmonary vascular remodeling: role in redox-sensitive regulation of tissue element by thrombin. Circ Res 98: 828836. 10 MKL1 Regulates HPH in Rats 35. Raychaudhuri B, Dweik R, Connors MJ, Buhrow L, Malur A, et al. Nitric oxide blocks nuclear factor-kappaB activation in alveolar macrophages. American Journal of Respiratory Cell and Molecular Biology 21: 311316. 36. Voraberger G, Schafer R, Stratowa C Cloning of the human gene 1313429 for intercellular adhesion molecule 1 and evaluation of its 59-regulatory area. Induction by cytokines and phorbol ester. J Immunol 147: 27772786. 37. Cybulsky MI, Gimbrone MA, Jr. Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 251: 788791. 38. Stenmark KR,.Cle cells. J Mol Cell Cardiol 46: 748 757. 19. Kong X, Fang M, Li P, Fang F, Xu Y HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells. J Mol Cell Cardiol 46: 292299. 20. Xu Y, Luchsinger L, Lucey EC, Smith BD The impact of class II transactivator mutations on bleomycin-induced lung inflammation and fibrosis. American Journal of Respiratory Cell and Molecular Biology 44: 898905. 21. Zhao L, Mason NA, Morrell NW, Kojonazarov B, Sadykov A, et al. Sildenafil inhibits hypoxia-induced pulmonary hypertension. Circulation 104: 424428. 22. Berkenbosch JW, Baribeau J, Perreault T Decreased synthesis and vasodilation to nitric oxide in piglets with hypoxia-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 278: L276283. 23. Vergadi E, Chang MS, Lee C, Liang OD, Liu X, et al. Early macrophage recruitment and alternative activation are essential for the later improvement of hypoxia-induced pulmonary hypertension. Circulation 123: 19861995. 24. Hanaoka M, Kubo K, Yamazaki Y, Miyahara T, Matsuzawa Y, et al. Association of high-altitude pulmonary edema using the important histocompatibility complex. Circulation 97: 11241128. 25. Steiner MK, Syrkina OL, Kolliputi N, Mark EJ, Hales CA, et al. Interleukin-6 overexpression induces pulmonary hypertension. Circ Res 104: 236244, 228p following 244. 26. Chang SW TNF potentiates PAF-induced pulmonary vasoconstriction in the rat: role of neutrophils and thromboxane A2. J Appl Physiol 77: 28172826. 27. Stenmark KR, Davie NJ, Reeves JT, Frid MG Hypoxia, leukocytes, and the pulmonary circulation. J Appl Physiol 98: 715721. 28. Poiani GJ, Wilson FJ, Fox JD, Sumka JM, Peng BW, et al. Liposomeentrapped antifibrotic agent prevents collagen accumulation in hypertensive pulmonary arteries of rats. Circ Res 70: 912922. 29. Archer SL, Weir EK, Wilkins MR Standard science of pulmonary arterial hypertension for clinicians: new ideas and experimental therapies. Circulation 121: 20452066. 30. Chaouat A, Savale L, Chouaid C, Tu L, Sztrymf B, et al. Part for interleukin-6 in COPD-related pulmonary hypertension. Chest 136: 678687. 31. Li M, Riddle SR, Frid MG, El Kasmi KC, McKinsey TA, et al. Emergence of fibroblasts having a proinflammatory epigenetically altered phenotype in extreme hypoxic pulmonary hypertension. J Immunol 187: 2711 2722. 32. Oeckinghaus A, Hayden MS, Ghosh S Crosstalk in NF-kappaB signaling pathways. Nat Immunol 12: 695708. 33. Ryan S, Taylor CT, McNicholas WT Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome. Circulation 112: 26602667. 34. BelAiba RS, Djordjevic T, Bonello S, Artunc F, Lang F, et al. The serumand glucocorticoid-inducible kinase Sgk-1 is involved in pulmonary vascular remodeling: part in redox-sensitive regulation of tissue factor by thrombin. Circ Res 98: 828836. 10 MKL1 Regulates HPH in Rats 35. Raychaudhuri B, Dweik 
R, Connors MJ, Buhrow L, Malur A, et al. Nitric oxide blocks nuclear factor-kappaB activation in alveolar macrophages. American Journal of Respiratory Cell and Molecular Biology 21: 311316. 36. Voraberger G, Schafer R, Stratowa C Cloning of the human gene 1313429 for intercellular adhesion molecule 1 and analysis of its 59-regulatory region. Induction by cytokines and phorbol ester. J Immunol 147: 27772786. 37. Cybulsky MI, Gimbrone MA, Jr. Endothelial expression of a mononuclear leukocyte adhesion molecule for the duration of atherogenesis. Science 251: 788791. 38. Stenmark KR,.
