VX-765
VX-765 is an orally absorbed prodrug of VRT-043198, a potent and selective inhibitor of caspase-1 and 4. In cultures of peripheral blood mononuclear cells stimulated with bacterial products, VRT-043198 inhibited the release of Interleukin (IL)-1β and IL-18, but had no affect the secretion of other cytokines including IL-α, TNFα, IL-6 and IL-8
Product Name:
VX-765
>Also Known As:
N/A
>Catalog No.:
F7120
>Size:
5 mg
>CAS:
273404-37-8
>Formula:
C24H33ClN4O6
>Molecular Weight:
509 Da
>Form:
Lyophilized powder
>Quality Assurance:
>98% by HPLC and NMR
>Source:
Synthetic
>Storage:
Eligible for room temperature shipping. Store at 2-8°C upon receiving
>PDF Data Sheet:
Download PDF datasheet
>Image(s):
N/A
>Shipping Method:
Room temperature shipping
>References:
1. Wannamaker W, et al. (2007) J Pharmacol Exp Ther 2007,321:509-516.
2. Doitsh G, et al. (2014) Nature 2014,505:509-514. E-3810 18481275
