VE-821
VE-821 is a potent and selective ATP competitive inhibitor of ataxia-telangiectasia and Rad3-related protein (ATR) with IC50 of 26 nM in cell-free assays, with minimal activity against ATM, DNA-PK, and mTOR. It augments DNA damage and cell death of cancer cells in response to radiation, also sensitizes cancer cells to chemotherapy.
Product Name:
VE-821
>Also Known As:
3-Amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-2-pyrazinecarboxamide
>Catalog No.:
F8130
>Size:
5 mg
>CAS:
1232410-49-9
>Formula:
C18H16N4O3S
>Molecular Weight:
368.41 Da
>Form:
Lyophilized powder
>Quality Assurance:
>98% by HPLC and NMR
>Source:
Synthetic
>Storage:
Eligible for room temperature shipping. Store at -80°C upon receiving
>PDF Data Sheet:
Download PDF datasheet
>Image(s):
N/A
>Shipping Method:
Room temperature shipping
>References:
1. Reaper PM, et al. (2011) Nat Chem Biol, 7(7), 428-430.
2. Prevo, R, et al. (2012) Cancer Biol Ther, 13(11) 1072-1081.
3. Huntoon, CJ, et al. (2013) Cancer Res, 73(12) 3683-3691. A939572 18482001
