UbE3A (E6AP)
UbE3A (also called E6AP) is a 100 kDa HECT (homologous to E6AP carboxyl terminus) domain ubiquitin ligase containing two E2 binding sites for UbcH7 and UbcH8. UbE3A was found to bind to the human papillomavirus (HPV) oncoprotein E6 and mediate ubiquitination of p53. A frameshift mutation in the UbE3A gene leads to loss of function and causes Angelman Syndrome.
Product Name:
UbE3A (E6AP)
>Also Known As:
AS; ANCR; E6-AP; E6AP; HPVE6A; EPVE6AP
>Catalog No.:
K1411
>Size:
50 µg
>Molecular Weight:
100.7 kDa
>Species:
Human
>Source:
Bacterial recombinant
>Stock:
20 mM Tris, 150 mM NaCl, 2 mM βME, 10% Glycerol
>Concentration:
See tube label
>Quality Assurance:
~90% by SDS-PAGE, see datasheet for gel image
>Storage:
Store at -80°C; avoid multiple freeze-thaw cycles
>PDF Data Sheet:
PDF Datasheet
>NCBI RefSeq:
NM_000462.3
>Image(s):
Please click product PDF datasheet above to view a representative SDS-PAGE of UbE3A.
>Shipping Method:
Dry ice shipping
>References:
1. Scheffner M, et al. (1990) Cell 63, 11291136.
2. Scheffner M, et al. (1993) Cell 75, 495505.
3. Abaied L, et al. (2009) Am J Med Genet Part A 152A, 141146.
4. Ronchi VP, et al. (2013) JBC 288, 1034910360. Cabozantinib 18475281
